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http://dx.doi.org/10.5012/jkcs.2021.65.3.203

Synthesis, Characterization and in vitro Antibacterial Studies on Mixed Ligand Complexes of Iron(III) Based on 1,10-phenanthroline  

Tigineh, Getinet Tamiru (Bahir Dar University, Science College, Chemistry Department)
Sitotaw, Getu (Bahir Dar University, Science College, Chemistry Department)
Workie, Amogne (Institute of Chemistry, Academia Sinica)
Abebe, Atakilt (Bahir Dar University, Science College, Chemistry Department)
Publication Information
Journal of the Korean Chemical Society / v.65, no.3, 2021 , pp. 203-208 More about this Journal
Abstract
As part of our attempt to discover novel active compounds against multi-drug resistant pathogens, we hereby report two new complexes of iron(III) with formulae: [Fe(L1)2(H2O)2]Cl3 and [Fe(L1)2(L2)(H2O)]Cl2 where L1 = 1,10-phenanthroline (C12H8N2) and L2 = guanide (C5H4N5O-). The synthesized complexes were characterized using spectroscopic analysis (ESI-MS, ICP-OES, FT-IR, and UV-Vis), cyclic voltammetry, CHN analysis, gravimetric chloride determination, melting point determination, and conductance measurement. Octahedral geometries are assigned to both complexes. In vitro antibacterial activity was tested on two Gram-positive (Staphylococcus aureus, Streptococcus epidermidis) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria using the disc diffusion method. The complexes demonstrated appreciable activity against these pathogens. Interestingly, the [Fe(L1)2(L2)(H2O)]Cl2 complex manifested a higher degree of inhibition against the drug-resistant Gram-negative bacteria than the commercially available drug, namely erythromycin.
Keywords
Iron(III); Mixed ligand complexes; 1,10-Phenanthroline; Guanide; Antibacterial activity;
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