[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/jkcs.2018.62.5.377

Design, Synthesis and Biological Evaluation of Some Novel Chalcones-sulphonamide Hybrids

Khanusiya, Mahammadali (Department of Chemistry, The HNSB Ltd Science College)
Gadhawala, Zakirhusen (Department of Chemistry, The HNSB Ltd Science College)

Publication Information

Journal of the Korean Chemical Society / v.62, no.5, 2018 , pp. 377-385 More about this Journal

Abstract

A new class of Chalcone-Sulphonamide hybrids has been designed by condensing appropriate sulphonamide scaffold with substituted chalcones tethered by chloroacetyl chloride as a multi-target drug for therapeutic treatment. Chalcones were prepared by Claisen-Schmidt condensation of a substituted aldehyde with para aminoacetophenone. These Chalcone-Sulphonamide hybrids were screened by means of their antibacterial activity by NCCLS method. Among all these compounds, 5e and 5c displayed more potent growth inhibitory activity against Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria respectively. Further, these hybrids were evaluated for their antifungal activity, among all hybrid 5a exhibited potent antifungal activity. The synthesized compounds were characterized by FT-IR, $^1HNMR$ , $^{13}CNMR$ and HR-LCMS and spectral study supports the structures of synthesized Chalcone-Sulphonamide hybrids.

Keywords

Chalcones; Sulphonamide scaffold; Antibacterial; Antifungal;

Citations & Related Records

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