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http://dx.doi.org/10.5012/jkcs.2016.60.4.245

An Improved Protocol on the Synthesis of Thiazolo[3,2-a]pyrimidine Using Ultrasonic Probe Irradiation  

Tan, Sian Hui (School of Marine Science and Environment, Universiti Malaysia Terengganu)
Chuah, Tse Seng (School of Food Science and Technology, Universiti Malaysia Terengganu)
Chia, Poh Wai (Institute of Marine Biotechnology, Universiti Malaysia Terengganu)
Publication Information
Journal of the Korean Chemical Society / v.60, no.4, 2016 , pp. 245-250 More about this Journal
Abstract
An improved protocol on the synthesis of thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives are reported. Previously, the thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives were prepared in a two-step procedure. Under the improved procedure, the thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was readily prepared in a one-step reaction. This procedure was found to be more efficient than the previous protocol and also compared to the ultrasound bath and conventional heating methods in terms of yield and reaction time.
Keywords
One-pot three component synthesis; Thiazolo[3; 2-a]pyrimidine; Ultrasound; Solvent- and catalyst-free reaction;
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