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http://dx.doi.org/10.5012/jkcs.2015.59.6.493

An Efficient Method for the Production of Cyclohexylamine from Cyclohexanone and Ammonia over Cu-Cr-La/γ-Al2O3  

Qin, Shuanglin (School of Pharmacy, Jiangxi Science and Technology Normal University)
Wang, Pan (First Teaching Hospital of Tianjin University of Traditional Chinese Medicine)
Huang, Shuangping (School of Pharmacy, Jiangxi Science and Technology Normal University)
Liu, Shuai (School of Pharmacy, Jiangxi Science and Technology Normal University)
Wang, Gaopeng (School of Pharmacy, Jiangxi Science and Technology Normal University)
Wang, Liping (School of Pharmacy, Jiangxi Science and Technology Normal University)
Sun, Meng (School of Pharmacy, Jiangxi Science and Technology Normal University)
Wang, Xiaoji (School of Pharmacy, Jiangxi Science and Technology Normal University)
Publication Information
Journal of the Korean Chemical Society / v.59, no.6, 2015 , pp. 493-498 More about this Journal
Abstract
The reductive amination of cyclohexanone with ammonia over Cu-Cr-a/γ-Al2O3 was investigated. It was found that a proper solvent with high solubility of ammonia and 4Å molecular sieves for the elimination of generated water contributed to the formation of cyclohexylamine in the premixing process. In addition, the addition of ammonia in the fixedbed reactor could obviously improve the conversion of cyclohexanone to cyclohexylamine. Finally, reaction conditions including reaction temperature, hydrogen pressure and charging rate of the premix were optimized. Under the optimized conditions, cyclohexylamine was obtained in 83.06% yield.
Keywords
Reductive amination; Cyclohexylamine; Cyclohexanone; $Cu-Cr-La/{\gamma}-Al_2O_3$; Premixing process;
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