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http://dx.doi.org/10.5012/jkcs.2014.58.5.450

Synthesis and Characterization of Novel Oxadiazole Derivatives from Benzimidazole  

Vishwanathan, Balasubramanaya (Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University)
Gurupadayya, Bannimath (Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University)
Publication Information
Journal of the Korean Chemical Society / v.58, no.5, 2014 , pp. 450-455 More about this Journal
Abstract
In the present study, a series of novel N-(1H-benzo[d]imidazol-2-yl)methyl-5-[(hetero)aryl-1,3,4-oxadiazol-2-yl]methanamine (4a-4j) were efficiently synthesized. Condensation of hydrazide derivative 3 with various carboxylic acid derivatives yielded N-[(1H-benzo[d]imidazol-2-yl)methy](5-substituted-1,3,4-oxadiazol-2-yl)methanamine (4a-4j) and compound 5-{[(1H-benzo[d]imidazol-2-yl)methylamino]methyl}-1,3,4-oxadiazole-2-thiol (4k) was obtained on treating hydrazide 3 with carbon disulfide. All the newly synthesized analogues were characterized by IR, $^1H$ NMR, $^{13}C$ NMR and mass spectral data.
Keywords
Benzimidazole; Oxadiazole;
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