[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/jkcs.2014.58.4.377

Antimicrobial Activities of Novel 3-Substituted [1,2,4] Triazolo[4,3-b]pyridazines Derivatives

Ruso, Jayaraman Sembian (Department of Polymer Science, Maramalai Campus, University of Madras)
Rajendiran, Nagappan (Department of Polymer Science, Maramalai Campus, University of Madras)
Srinivas, Chowdappa (Department of Microbiology, Janabharathi Campus)
Murthy, Konappa Narasimha (Department of Microbiology, Janabharathi Campus)
Soumya, Krishnamurthy (Department of Microbiology, Janabharathi Campus)

Publication Information

Journal of the Korean Chemical Society / v.58, no.4, 2014 , pp. 377-380 More about this Journal

Abstract

A noval derivatives of 3-substituted[1,2,4]triazolo[4,3-b]pyridazine (4a-4o) and 7,8,9,10-tetrahydrobenzo[4,5] thieno[2,3-d][1,2,4]triazolo[4,3-b]pyridazine (7a-7l) is prepared by the reaction of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative, followed by subjecting the intermediate directly to oxidative cyclization employing the mixture of $Me_4NBr$ and Oxone. These derivatives were subjected to preliminary antimicrobial activities against microorganism. All these compounds exhibit good to moderate activity.

Keywords

1,2,4 Triazolopyridazine; Aromatic aldehyde antifungal and antibacterial;

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Times Cited By KSCI : 1 (Citation Analysis)

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