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http://dx.doi.org/10.5012/jkcs.2014.58.2.186

Efficient Synthesis of Novel 3-Substituted Coumarin-3-carboxamide  

Sheikhhosseini, Enayatollah (Department of Chemistry, Faculty of Science, Kerman Branch, Islamic Azad University)
Balalaie, Saeed (Peptide Chemistry Research Center, K. N. Toosi University of Technology)
Bigdeli, Mohammad Ali (Faculty of Chemistry, Kharazmi University)
Habibi, Azizollah (Faculty of Chemistry, Kharazmi University)
Moghaddam, Hamed Piri (Department of Chemistry, Sharif University of Technology)
Publication Information
Journal of the Korean Chemical Society / v.58, no.2, 2014 , pp. 186-192 More about this Journal
Abstract
A series of novel pseudopeptides contained coumarin skeleton were synthesized through the Ugi-four-component reaction. The 3-substituted coumarin-3-carboxamides were formed through reaction of benzaldehyde derivatives, anilines, coumarin-3-carboxylic acid and isocyanides with high yields and high bond-forming efficiency at room temperature. These novel amidated coumarins exhibit brilliant fluorescence in range of 535-547 nm in chloroform.
Keywords
3-Substituted amidated coumarins; Ugi-4CR; Pseudopeptides; Fluoresence property;
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