Browse > Article
http://dx.doi.org/10.5012/jkcs.2014.58.1.92

Stimuli-Sensitive Poly(NIPA-co-APA) Hydrogels for the Controlled Release of Keterolac Tromethamine  

Kim, Yonghyun (Anastro Laboratory, Department of Chemistry, Changwon National University)
Babu, V. Ramesh (Anastro Laboratory, Department of Chemistry, Changwon National University)
Rao, K.S.V. Krishna (Department of Chemistry, Yogi Vemana University)
Lim, Jae-Min (Anastro Laboratory, Department of Chemistry, Changwon National University)
Thangadurai, T. Daniel (Department of Nanotechnology, College of Engineering, Sri Ramakrishna Institutions)
Lee, Yong-Ill (Anastro Laboratory, Department of Chemistry, Changwon National University)
Publication Information
Journal of the Korean Chemical Society / v.58, no.1, 2014 , pp. 92-99 More about this Journal
Abstract
The pH sensitive hydrogels composed of N-isopropylacrylamide (NIPA) and acryloyl phenylalanine (APA) were prepared by redox polymerization using N,N'-methylenebisacrylamide (MBA) as a crosslinker. Anti-inflammatory and analgesic agent, Keterolac Tromethamine (KT), was loaded successfully into poly(NIPA-co-APA) copolymeric hydrogels by swelling equilibrium method. To understand the nature of drug in the polymeric matrix, the newly synthesized drug loaded poly(NIPA-co-APA) copolymeric hydrogels were characterized by using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) techniques. The scanning electron microscopy (SEM) technique result indicates the spherical smooth surface of the hydrogels. The drug (KT) releasing nature of the poly(NIPA-co-APA) hydrogels was studied in pH 1.2 and 7.4. Effects of drug loading, crosslinking agent, pH and the ionic strength of the external medium on swelling of hydrogels were also investigated.
Keywords
Hydrogel; Keterolac tromethamine; Controlled Release; Stimuli-responsive;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Gundogan, N.; Melekaslan, D.; Okay, O. J. Appl. Poly. Sci. 2012, 94, 135.
2 Peppas, N. A.; Mikos, A. G. Preparation Methods and Structure of Hydrogels. In Hydrogels in Medicine and Pharmacy; Peppas, N. A., Ed.; CRC Press: Boca Raton, Florida, 1986; pp 1-25.
3 Allan, S. H. Adv. Drug Delivery Rev. 2002, 54, 3.   DOI   ScienceOn
4 Peppas, N. A.; Bures, P.; Leobandung, W.; Ichikawa, H.; Eur. J. Pharm. Biopharm. 2000, 50, 27.   DOI   ScienceOn
5 Deshmukh, M. V.; Vaidya, A. A.; Kulkarni, M. G.; Rajamohanan, P. R.; Ganapathy, S. Polymer 2000, 41, 7951.   DOI   ScienceOn
6 Puskas, J. E.; Chen, Y.; Dahman, Y.; Padavan, D. J. Polym. Sci. Part A: Polym. Chem. 2004, 42, 3091.   DOI   ScienceOn
7 Vyavahare, N.; Kohn, J. J. Polym. Sci. Part A: Polym. Chem. 1994, 32, 1271.
8 Nathan, A.; Zalipsky, S.; Kohn, J. J. Bioact. Compat. Polym. 1994, 9, 239.
9 Lin, H. B.; Sun, W.; Mosher, D. F.; Garcia-Echeverria, C.; Schaufelberger, K.; Lelkes, P. I.; Cooper, S. L. J. Biomed. Mater. Res. 1994, 28, 329.   DOI   ScienceOn
10 Salhi, F.; Lam, J. W. Y.; Cheuk, K. K. L.; Cha, J. A. K.; Tan, B. Z. Polymer Preprint 2000, 41, 1185.
11 Song, H.; Chu, C. C. J. Appl. Poly. Sci. 2012, 124, 3840.   DOI   ScienceOn
12 Sato, M.; Mutsumi Inata, M.; Yamaguchi, I. J. Appl. Poly. Sci. 2012, 126, E298.   DOI   ScienceOn
13 Angiolini, L.; Caretti, D.; Giorgini, L.; Salatelli, E.; Altomare, A.; Carlini, C.; Solaro, R. Polymer 1998, 39, 6621.   DOI   ScienceOn
14 Erbil, C.; Aras, S.; Uyanik, N. J. Polym. Sci. Part A: Polym. Chem. 1999, 37, 1847.   DOI
15 Vesterinen, E.; Dobrodumov, A.; Tenhu, H. Macromolecules 1997, 30, 1311.   DOI   ScienceOn
16 Chen, G.; Hoffman, A. S. Nature 1995, 373, 49.   DOI   ScienceOn
17 Raman, K.; Ramamoorthy, R.; Reddy, B. S. R. React. Funct. Polym. 2005, 62, 215.   DOI   ScienceOn
18 Vaidya, A. A.; Lele, B. S.; Kulkarni, M. G.; Mashelkar, R. A. Biotechnol. Bioeng. 1999, 64, 418   DOI
19 Serizawa, T.; Uemura, M.; Kaneko, T.; Akashi, M. J. Polym. Sci. Part A: Polym. Chem. 2002, 40, 3542.   DOI   ScienceOn
20 Wang, M.; Fang, Y.; Hu, D. React. Funct. Polym. 2001, 48, 215.   DOI   ScienceOn
21 Grottum, J. A.; Erikson, U.; Grasdalen, H.; Staurnes, M. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 1998, 120, 469.   DOI   ScienceOn
22 Yan, L.; Zhu, Q.; Kenkare, P. U. J. Appl. Poly. Sci. 2000, 78, 1971.   DOI
23 Krishna Rao, K. S. V.; Vijaya Kumar, N. B.; Subha, M. C. S.; Sairam, M.; Aminabhavi, T. M. Carbohyd. Polym. 2006, 66, 333.   DOI   ScienceOn
24 Cui, Z. F.; Guan, Y. X.; Chen, J. L.; Yao, S. J. J. Appl. Poly. Sci. 2005, 96, 1734.   DOI   ScienceOn
25 Shin, B. C.; Jhon, M. S.; Lee, H. B.; Yuk, S. H. Eur. Polym. J. 1998, 34,171.   DOI   ScienceOn
26 Casolaro, M.; Paccagnini, E.; Mendichi R.; Ito, Y. Macromolecules 2005, 38, 2460.   DOI   ScienceOn
27 Baljit, S. Int. J. Pharm. 2007, 334, 1.   DOI   ScienceOn
28 Peppas, N. A. Bioavailability and the Pharmacokinetic Control of Drug Response; Wiley: New York, 1980.
29 Dogu, Y.; Okay, O. J. Appl. Poly. Sci. 2006, 99, 37.   DOI   ScienceOn
30 Pharmacopoeia of India; Controller of publications: Delhi, India, 1985.
31 Ramesh Babu, V.; Kim, C.; Kim, S.; Ahn, C. Lee, Y. I. Carbohyd. Polym. 2010, 81, 196.   DOI   ScienceOn
32 Soppimath, K. S.; Aminabhavi, T. M.; Kulkarni, A. R.; Rudzinski, W. E. J. Controlled Release 2001, 70, 1.   DOI   ScienceOn