[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/jkcs.2014.58.1.62

Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives

Mhaske, Pravin C. (Post Graduate Department of Chemistry, S. P. Mandali's Sir Parashurambahu College, University of Pune)
Shelke, Shivaji H. (Department of Chemistry, HPT Arts and RYK Science College)
Raundal, Hemant N. (Department of Chemistry, HPT Arts and RYK Science College)
Jadhav, Rahul P. (Department of Chemistry, HPT Arts and RYK Science College)

Publication Information

Journal of the Korean Chemical Society / v.58, no.1, 2014 , pp. 62-67 More about this Journal

Abstract

In the present study a novel series of (2-substituted-4-methylthiazol-5-yl)(4-substituted piperazin-1-yl)methanone derivatives were synthesized by reaction of 2-substituted-4-methylthiazole-5-carboxylic acid with N-substituted benzyl piperazine by using 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDCl) and 1-hydroxybenzotriazole (HOBt) in DMF. All the newly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro antibacterial activity. Most of the compounds show moderate to good antimicrobial activity.

Keywords

Thiazole; Piperazine; EDCl-HOBt; Antimicrobial activity;

Citations & Related Records

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