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http://dx.doi.org/10.5012/jkcs.2013.57.4.439

Development of Polymeric Blend Microspheres from Chitosan-Hydroxypropylmethyl Cellulose for Controlled Release of an Anti-Cancer Drug  

Reddy, Lakshmi C. Narayana (Department of Chemistry, Sri Krishnadevaraya University)
Reddy, Rama Subba P. (Department of Chemistry, Yogi Vemana University)
Rao, Krishna K.S.V. (Department of Chemistry, Yogi Vemana University)
Subha, M.C.S. (Department of Chemistry, Sri Krishnadevaraya University)
Rao, Chowdoji K. (Department of Polymer Science & Tech., Sri Krishnadevaraya University)
Publication Information
Journal of the Korean Chemical Society / v.57, no.4, 2013 , pp. 439-446 More about this Journal
Abstract
Chitosan (CS) and hydroxypropylmethyl cellulose (HPMC) blend microspheres were prepared by water-in-oil emulsion technique and were loaded with an anti-cancer drug 5-fluorouracil (5-FU). CS-HPMC microspheres were characterized by Fourier transform infrared spectroscopy to confirm the cross-linking reaction. Scanning electron microscopy (SEM) was also used to assess the surface morphology of particles prepared. The quantity of release of 5-FU from the microspheres have been studied in terms of blend composition and amount of cross-linking agent. Differential scanning calorimetry and X-ray diffraction techniques indicated a uniform distribution of 5-FU particles in microspheres, whereas SEM suggested the spherical structure of the microspheres with slight rough surface. The in vitro drug release indicated that the particle size and release kinetics depend upon blend composition, amount of cross-linking agent used and amount of 5-FU present in the microspheres.
Keywords
Chitosan; Hydroxypropylmethyl cellulose; Microspheres; Drug release; Anti-cancer drug;
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1 Chowhan, Z. T. Role of Binders in Moisture-Induced Hardness Increase in Compressed Tablets and Its Effect on in Vitro Disintegration and Dissolution. J. Pharm. Sci. 1980, 69, 1-4.   DOI
2 Lim, S. T.; Forbes, B.; Berry, D. J.; Martin, G. P.; Brown, M. B. In Vivo Evaluation of Novel Hyaluronan/Chitosan Microparticulate Delivery Systems for the Nasal Delivery of Gentamicin in Rabbits. Int. J. Pharm. 2002, 231, 73-82.   DOI   ScienceOn
3 Cadee, J. A.; de Groot, C. J.; Jiskoot, W.; Den Otter, W.; Hennink, W. E. Release of Recombinant Human Interleukin-2 from Dextran-Based Hydrogels. J. Control. Rel. 2002, 78, 1-13.   DOI   ScienceOn
4 Ryoichi, M.; Honda, R.; Takahashi, Y. Development of Oral Controlled Release Preparations, a PVA Swelling Controlled Release System (SCRS). II. In Vitro and in Vivo Evaluation. J. Control. Rel. 2000, 68, 115-120.   DOI   ScienceOn
5 Krogel, I.; Bodmeier, R. Developemnt of a Multifunctional Matrix Drug Delivery System Surrounded by an Impermeable Cylinder. J. Control. Rel. 1999, 61, 43-50.   DOI   ScienceOn
6 Holgado, M. A.; Caraballo, I.; Alvarez-Fuentes, J.; Fernandez-Hervas, M. J.; Fernandez-Arevalo, M.; Rabsco, A. M. Int. J. Pharm. 1995, 118, 151.   DOI   ScienceOn
7 Perez-Marcos, B.; Ford, J. L.; Armstrong, D. J.; Elliott, P. N.; Rostron, C.; Hogan, J. E. Influence of pH on the Release of Propranolol Hydrochloride from Matrices Containing Hydroxypropylmethyl Cellulose K4M and Carbopol 974. J. Pharm. Sci. 1996, 85, 330-334.   DOI
8 Tahara, K.; Yamamoto, K.; Nishihata, T. Overall Mechanism Behind Matrix Sustained Release(SR) Tablets Prepared with Hydroxypropyl Methylcellulose 2910 J. Control. Rel. 1995, 35, 59-66.   DOI   ScienceOn
9 Sezer, A. D.; Akbuga, J. Comparison on In Vitro Characterization of Fucospheres and Chitosan Microspheres Encapsulated Plasmid DNA (pGM-CSF): Formulation Design and Release Characteristics. AAPS. Pharm. Sci. Tech. 2009, 10, 1193-1199.   DOI
10 Kahtani Ahmed, A. L.; Bhojya Naik, H. S.; Sherigara, B. S. Synthesis and Characterization of Chitosan-Based pHSensitive Semi-Interpenetrating Network Microspheres for Controlled Release of Diclofenac Sodium. Carbohyd. Res. 2009, 344, 699-706.   DOI   ScienceOn
11 Vazquez, M. J.; Casalderrey, M.; Duro, R.; Gomez-AJL, Martinez-PR, Souto, C. Atenlol Release from Hydrophilic Matrix Tablets with Hydroxyl Propylmethyl Cellulose (HPMC) Mixtures as Gelling Agent: Effects of Viscosity of the HPMC Mixture. Eur. J. Pharm. Sci. 1996, 4, 39-48.   DOI   ScienceOn
12 Peppas, N. A.; Khare, A. R. Preparation, Structure and Diffusional Behavior of Hydrogels in Controlled Release. Adv. Drug Delivery Rev. 1993, 11, 1-35.   DOI   ScienceOn
13 Cory, B.; Martin, K.; Amanda, C.; Kyekyoon, K.; Daniel, W. P. Precise Control of PLG Microsphere Size Provides Enhanced Control of Drug Release Rate. J. Control. Rel. 2002, 82, 137-147.   DOI   ScienceOn
14 Salsa, T.; Veiga, F.; Pina, M. E. Oral Controlled-Release Dosage Forms. I. Cellulose Ether Polymers in Hydrophilic Matrices. Drug Dev. Ind. Pharm 1997, 23, 929-938.   DOI   ScienceOn
15 Krishna Rao, K. S. V.; Naidu, B. V. K.; Subha, M. C. S.; Aminabhavi, T. M. Controlled Release of Ibuprofen and Diclofenac Sodium through Beads of Alginate and Hydroxyethyl Cellulose Blends. J. Appl. Polym. Sci. 2006, 102, 5708-5718.   DOI   ScienceOn
16 Campos-Aldrete, M. E.; Villafuerte-Robles, L. Influence of the Viscosity Degree and the Particle Size of HPMC on Metronidazole Release from Matrix Tablets. Eur. J. Pharm. Biopharm. 1997, 43, 173-178.   DOI   ScienceOn
17 Ford, J. L.; Rubinstein, M. H.; Hogan, J. E. Formulation of Sustained Release Promethazine Hydrochloride Tablets Using Hydroxypropylmethylcellulose Matrices. Int. J. Pharm. 1985, 24, 327-338.   DOI   ScienceOn
18 Ford, J. L.; Rubinstein, M. H.; Hogan, J. E. 1985. Propranolol Hydrochloride and Aminophylline Release from Matrix Tablets Containing Hydroxypropylmethylcellulose. Int. J. Pharm. 1985, 24, 339-350.   DOI   ScienceOn
19 Cuna, M.; Alonso, M. J.; Torres, D. Preparation and in Vivo Evaluation of Mucoadhesive Microparticles Containing Amoxycillin-Resin Complexes for Drug Delivery to the Gastric Mucosa. Eur. J. Pharm. Biopharm. 2001, 51, 199-205.   DOI   ScienceOn
20 Chowdary, K. P. R.; Rao, Y. S. Design and in Vitro and in Vivo Evaluation of Mucoadhesive Microcapsules of Glipizide for Oral Controlled Release: A Technical Note. AAPS. Pharm. Sci. Tech. 2003, 4, 87-92.   DOI   ScienceOn
21 Sudha, C. A.; Lata, S. M.; Aminabhavi, T. M. Interpenetrating Polymer Network Blend Microspheres of Chitosan and Hydroxyethyl Cellulose for Controlled Release of Isoniazid. Int. J. Bio. Macromol. 2010, 47, 171-179.   DOI   ScienceOn
22 Hos, W. M.; Miyazaki, S.; Takeda, M. Sustained Release of Indomethacin from Chitosan Granules. Chem. Pharm. Bull. 1985, 33, 3986-3992.   DOI   ScienceOn
23 Ajit, P. R.; Namdev, B. S.; Sangamesh, A. P.; Aminabhavi, T. M. Novel Interpenetrating Polymer Network Microspheres of Chitosan and Methylcellulose for Controlled Release of Theophylline. Carbohyd Polym 2007, 69, 678-687.   DOI   ScienceOn
24 Pillay, V.; Fassihi, R. A Novel Approach for Constant Rate Delivery of Highly Soluble Bioactives from a Simple Monolithic System. J. Control. Rel. 2000, 67, 67-78.   DOI   ScienceOn
25 Van, T. N.; Ng, C. H.; Aye, K. N.; Trang, T. S.; Stevens, W. F. Production of High-Quality Chitin and Chitosan from Preconditioned Shrimp Shells. J. Chem. Tech. Biotech. 2006, 81(7), 1113-1118.   DOI   ScienceOn
26 Miyazaki, S.; Ishi, K.; Nadai, T. The Use of Chitin and Chitosan as Drug Carriers. Chem. Pharm. Bull. 1981, 29, 3067-3069.   DOI   ScienceOn
27 Sawayanagi, Y.; Nambu, N.; Nagai, T. Directly Compressed Tablets Containing Chitin or Chitosan in Addition to Lactose or Potato Starch. Chem. Pharm. Bull. 1982, 30, 2935-2940.   DOI   ScienceOn
28 Sawayanagi, Y.; Nambu, N.; Nagai, T. Enhancement of Dissolution Properties of Prednisolone from Ground Mixtures with Chitin or Chitosan. Chem. Pharm. Bull. 1983, 31, 2507-2509.   DOI
29 Peppas, L. B.; Peppas, N. A. The Equilibrium Swelling Behavior of Porous and Non-Porous Hydrogels. In Absorbent Polymer Technology; Brannon-Peppas, L., Harland, R. S., Eds.; Elsevier: Amsterdam, 1990; pp 67-102.
30 Peppas, L. B.; Preparation and Characterization of Crosslinked Hydrophilic Networks. In Absorbent Polymer Technology; Brannon-peppas, L., Harland, R. S., Elsevier: Amsterdam, 1990; pp 45-66.
31 Siepmann, J.; Peppas, N. A.; Modeling of Drug Release from Delivery Systems Based on Hydroxypropyl Methylcellulose (HPMC). Adv. Drug. Deliv. Rev. 2001, 48, 139-157.   DOI   ScienceOn