Browse > Article
http://dx.doi.org/10.5012/jkcs.2013.57.2.241

Design, Synthesis and Antibacterial Activity Studies of Novel Quinoline Carboxamide Derivatives  

Shivaraj, Yellappa (Department of Chemistry, Government Science College)
Naveen, Malenahalli H. (Department of Chemistry, Government Science College)
Vijayakumar, Giriyapura R. (Department of Chemistry, Tumkur University)
Kumar, Doyijode B. Aruna (Department of Chemistry, Tumkur University)
Publication Information
Journal of the Korean Chemical Society / v.57, no.2, 2013 , pp. 241-245 More about this Journal
Abstract
A series of novel quinoline-6-carboxamides and 2-chloroquinoline-4-carboxamides were synthesized by the reaction of their analogous carboxylic acids with various amine derivatives in the presence of base TEA and protecting agent BOP at room temperature. Synthesized compounds were confirmed by spectral characterization viz IR, $^1H$-NMR, and MS. Antibacterial activity carried out against Escherichia coli and Staphyllococcus aureus indicated that the synthesized compounds were active against these microorganisms.
Keywords
Quinoline-6-carboxamides; 2-Chloro quinoline-4-carboxamides; Antibacterial activity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Roma, G.; Grossi, G.; Di Braccio, M.; Piras, D.; Ballabeni, V.; Tognolini, M.; Bertoni, S.; Barocelli. E. Eur. J. Med. Chem. 2008, 43, 1665.   DOI   ScienceOn
2 Venkat Reddy, G.; et al. Eur. J. Med. Chem. 2009, 44, 1570.   DOI   ScienceOn
3 Tomassoli, I.; et al. Eur. J. Med. Chem. 2011, 46, 1.   DOI   ScienceOn
4 Sliman, F.; Blairvacq, M.; Durieu, E.; Meijer, L.; Rodrigo, J.; Desmaele, D. Bioorg. Med. Chem. Lett. 2010, 20, 2801.   DOI   ScienceOn
5 Zhang, J.; Ke, X.; Tu, C.; Lin, J.; Ding, J.; Lin, L.; Fun, H. K.; You, X.; Guo, Z. Biometals. 2003, 16, 485.   DOI   ScienceOn
6 Tsuji, K.; Spears, G. W.; Nakamura, K.; Tojo, T.; Seki, N.; Sugiyama, A.; Matsuo, M. Bioorg. Med. Chem. Lett. 2002, 12, 85.   DOI   ScienceOn
7 Bu, X.; Chen, J.; Deady, L. W.; Smith, C. L.; Baguley, B. C.; Greenhalgh, D.; Yang, S.; Denny, W. A. Bioorg. Med. Chem. Lett. 2005, 13, 3657.   DOI   ScienceOn
8 Liu, J.-Y.; Yu, H.-L.; Quan, Z.-S.; Cui, X.; Piao, H.-R. Bioorg. Med. Chem. Lett. 2009, 19, 2392.   DOI   ScienceOn
9 Belloli, S.; et al. Neurochem. International, 2004, 44, 433.   DOI   ScienceOn
10 Wentland, M. P.; et al. Drug Des Discov. 1997, 15, 25.
11 Pelczar, M. J.; Chan, E. C. S. Laboratory Exercise in Microbiology; McGraw-Hill Inc: USA, 1997, Vo. 17, p 301.
12 Cruickshank, R.; Duguid, J. P.; Marmion, B. P.; Swain, R. H. A. Med. Microbiol. 1989, 201.
13 EUCAST Definitive Document. Determination of Minimum Inhibitory Concentrations (MICs) of Antimicrobial Agents by Agar Dilution. 2000, Vol. 6, pp 509−515.