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http://dx.doi.org/10.5012/jkcs.2013.57.2.227

Synthesis and Biological Evaluation of Novel Substituted-Imidazolidine Derivatives  

Husain, Asif (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University))
Bhutani, Rubina (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University))
Kumar, Deepak (Department of Chemistry, Changwon National University)
Shin, Dong-Soo (Department of Chemistry, Changwon National University)
Publication Information
Journal of the Korean Chemical Society / v.57, no.2, 2013 , pp. 227-233 More about this Journal
Abstract
A series of newer substituted-imidazolidine derivatives 3a-k were synthesized and assayed in vivo to investigate their anti-inflammatory, analgesic and antiulcer activity. The results of biological evaluation revealed that the three compounds, 4-[1,3-bis(4-hydroxy-3-methoxybenzyl)-2-imidazolidinyl]phenyldiethylamine (3g), 4-[1,3-bis(3-Ethoxy-4-hydroxybenzyl)-2-imidazolidinyl] phenyldiethylamine (3h) and 4-(1,3-bis(benzo[d][1,3]dioxol-5-ylmethyl)-4-methylimidazolidin-2-yl)-N,N-diethylbenzenamine (3j) were good in their anti-inflammatory and analgesic actions. Additionally these derivatives showed superior GI safety profile as compared to that of the standard drug in terms of low severity index. The results are statistically treated for its significance.
Keywords
Imidazolidines; Anti-inflammatory; Analgesic; Ulcerogenic;
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