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http://dx.doi.org/10.5012/jkcs.2013.57.1.94

Synthesis and Biological Evaluation of Some Novel [4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines  

Mekala, Raghu Vardhan Reddy (Department of Chemistry, Kakatiya University)
Danda, Ravinder Reddy (Department of Chemistry, Mahatma Gandhi University)
Gadegoni, Hemalatha (Jayamukhi College of Pharmacy)
Publication Information
Journal of the Korean Chemical Society / v.57, no.1, 2013 , pp. 94-98 More about this Journal
Abstract
A new family of thiazole heterocycles, namely [4-(1H-benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines has been synthesized by the condensation of 4-(1H-Benzoimidazol-2-yl)-thiazol-2-ylamine with various aromatic aldehydes and N-[4-(1H-benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines through the cyclization of 1-(1H-benzoimidazol-2-yl)-2-bromo-ethanone with arylthiosemicarbazones. The target compounds are achieved by using 1-(1H-Benzoimidazol-2-yl)-ethanone as starting material. The chemical structures of all newly synthesized compounds were confirmed by their IR, $^1H$ NMR and Mass spectral data. Further the compounds were used to evaluate their antimicrobial activity and found that the appreciable antimicrobial activity by some of the title compounds.
Keywords
Benzoimidazol-2-yl-thiazole; Antibacterial activity; Antifungal activity;
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