Browse > Article
http://dx.doi.org/10.5012/jkcs.2012.56.4.464

Synthesis and Hydroxyl Radicals Scavenging Activity of 2-Pyridine-acetyl-N-trimethyl Chitosan Chloride  

Li, Rongchun (Department of Chemistry, Dezhou University)
Publication Information
Journal of the Korean Chemical Society / v.56, no.4, 2012 , pp. 464-467 More about this Journal
Abstract
A novel chitosan derivative with double quaternary ammonium salt-2-pyridine-acetyl-N-trimethyl chitosan chloride (PATMCS) was synthesized and the antioxidant activity of PATMCS against hydroxyl radicals was assessed. The results indicated that PATMCS had potent hydroxyl scavenging activity. The $IC_{50}$ of PATMCS was 0.13 mg/mL. PATMCS showed 100% scavenging effect at a dose of 0.8 mg/mL which markedly better than that of N-trimethyl chitosan chloride (TMCS). It was confirmed that quaternary chitosan derivatives showed potent antioxidant activity. PATMCS has double quaternary ammonium salt structure in the molecules. Therefore, the antioxidant activity of PATMCS was better than TMCS. The above results are theoretically fundamental for further development and making use of chitosan resources to prepare new antioxidants.
Keywords
Double quaternary chitosan; Synthesis; Antioxidant activity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Halliwell, B.; Gutteridge, J. M. C. Methods Enzymol. 1990, 86, 1.
2 Snyman, D.; Hanmman, J. H.; Kotze, J. S.; Rollings J. E.; Kotze, A. F. Carbohydr. Polym. 2002, 50, 145.   DOI
3 Britto, D.; Assis, O. B. G. International Journal of Biological Macromolecules 2007, 41, 198.   DOI
4 Jia, Z.; Shen, D.; Xu, W. Carbohydr. Res. 2001, 333, 1.   DOI   ScienceOn
5 Liu, Z. R.; Zhao, J. X. Journal of Qingdao University of Science and Technology 2006, 27, 317.
6 Baumann, H.; Faust, V. Carbohydr. Res. 2001, 331, 43.   DOI
7 Panicker, C. Y.; Varghese, H. T.; Philip, D.; Nogueira, H. I. S. Spectrochim. Acta, Part A 2006, 64, 744.   DOI
8 Chruszcz, K.; Baranska, M.; Czarniecki, K.; Boduszek, B.; Proniewicz, L. M. J. Mol. Struct. 2003, 648, 215.   DOI
9 Heras, A.; Rodriguez, N. M.; Ramos, V. M.; Agullu, E. Carbohydr. Polym. 2001, 44, 1.   DOI   ScienceOn
10 Guo, Z.; Xing, R.; Liu, S.; Yu, H.; Wang, P.; Li C.; Li, P. Bioorg. Med. Chem. Lett. 2005, 15, 4600.   DOI
11 Muzzarelli, R. A. A.; Tanfani, F. Carbohydr. Polym. 1985, 5, 297.   DOI
12 Lim, S. H.; Hudson, S. M. Carbohydr. Res. 2004, 39, 313.
13 Krajewska, B. Sep. Purif. Technol. 2005, 41, 305.   DOI
14 Kim, K. W.; Thomas, R. L. Food Chem. 2007, 101, 308.   DOI
15 Domard, A.; Rinaudo, M.; Terrassin, C. International Journal of Biological Macromolecules 1986, 8, 105.   DOI
16 Guo, Z.; Liu, H.; Chen, X.; Ji, X.; Li, P. Bioorg. Med. Chem. Lett. 2006, 16, 6348.   DOI
17 Liu, J.; Sun, H.; Dong, F.; Xue, Q.; Wang, G.; Qin, S.; Guo, Z. Carbohydr. Polym. 2009,78, 439.   DOI