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http://dx.doi.org/10.5012/jkcs.2012.56.3.341

Synthesis and Antimicrobial Evaluation of Some Novel 2-(4-Chlorophenylimino) thiazolidin-4-one Derivatives  

B'Bhatt, H. (Department of Chemistry, Hemchandracharya North Gujarat University)
Sharma, S. (Department of Chemistry, Hemchandracharya North Gujarat University)
Publication Information
Journal of the Korean Chemical Society / v.56, no.3, 2012 , pp. 341-347 More about this Journal
Abstract
A series of 2-(4-chlorophenylimino)-5-((3-(p-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl) methylene) thiazolidin-4-one ($\mathbf{3a-h}$) compounds were prepared from the 2-(4-chlorophenylimino) thiazolidin-4-one ($\mathbf{1}$) and 1-phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde ($\mathbf{2a-h}$). All compounds were characterized by elemental (C, H, N) analysis and spectral (FT-IR, $^1H$ NMR and GC-MS) analysis. These newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial activity was observed and evaluated against the bacterial strains like Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442) and against the fungal strains like Candida albicans (MTCC 227), Aspergillus niger (MTCC 282) and Aspergillus clavatus (MTCC 1323). All the synthesized compounds were found to possess moderate to excellent antimicrobial activity against above selected strains.
Keywords
2-(4-Chlorophenylimino) thiazolidin-4-one; Antibacterial activity; Anti fungal activity; Vilsmeier-Haack reaction; Knoevenagel condensation reaction;
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