[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/jkcs.2012.56.3.334

Synthesis and Biological Studies of Novel Biphenyl-3,5-dihydro-2H-thiazolopyrimidines Derivatives

Maddila, S. (School of Chemistry, University of KwaZulu-Natal)
Damu, G.L.V. (Department of Chemistry, Sri Venkateswara University)
Oseghe, E.O. (School of Chemistry, University of KwaZulu-Natal)
Abafe, O.A. (School of Chemistry, University of KwaZulu-Natal)
Rao, C. Venakata (Department of Chemistry, Sri Venkateswara University)
Lavanya, P. (Department of Chemistry, Sri Venkateswara University)

Publication Information

Journal of the Korean Chemical Society / v.56, no.3, 2012 , pp. 334-340 More about this Journal

Abstract

A new series of ethyl 2-(4-substitutedbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives ( $\mathbf{8a-j}$ ) were synthesized. The newly synthesized compounds were characterized by $\mathbf{IR}$ , $^1\mathbf{H}$ $\mathbf{NMR}$ , $^{13}\mathbf{C}$ $\mathbf{NMR}$ , $\mathbf{LCMS}$ $\mathbf{mass}$ and $\mathbf{C}$ , $\mathbf{H}$ , $\mathbf{N}$ analyses. All newly synthesized compounds were screened for their In vitro antioxidant activity (Scavenging of hydrogen peroxide, Scavenging of nitric oxide radical, and Lipid peroxidation inhibitory activity), antibacterial (Escheria coli, Pseudonmonas aeruginosa (gram-negative bacteria), Bacillus subtillis, Staphylococcus aureus (gram-positive bacteria)) and antifungal (Candida albicans Aspergillus niger) studies.

Keywords

Biphenyl-3,5-dihydro-2H-thiazolopyrimidines derivatives; Antioxidant activity; Antibacterial; Antifungal activities;

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