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http://dx.doi.org/10.5012/jkcs.2012.56.1.068

Synthesis and Biological Evaluation of Novel Isopropyl 2-thiazolopyrimidine-6-carboxylate Derivatives  

Kotaiah, Y. (Department of Chemistry, Sri Venkateswara University)
Krishna, N. Hari (Department of Chemistry, Sri Venkateswara University)
Raju, K. Naga (Department of Chemistry, Sri Venkateswara University)
Rao, C.V. (Department of Chemistry, Sri Venkateswara University)
Jonnalagadda, S.B. (Department of Chemistry, Sri Venkateswara University)
Maddila, Suresh (School of Chemistry, University of KwaZulu-Natal)
Publication Information
Journal of the Korean Chemical Society / v.56, no.1, 2012 , pp. 68-73 More about this Journal
Abstract
In the present study, we have synthesized novel Isopropyl 2-(4-substitutedbenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]-pyrimidine-6-carboxylate derivatives (6a-j). Elemental analysis, IR, $^1H$ NMR and mass spectral data elucidated structure of newly synthesized compounds. The newly synthesized compounds were screened for antiinflammatory and anti microbial studies. Their biological activity data of the 10 compounds indicates that two compounds posses potent anti-inflammatory and five have antimicrobial activities.
Keywords
Isopropyl 2-thiazolopyrimidine-6-carboxylate; Anti-inflammatory; Antibacterial; Antifungal activities;
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