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http://dx.doi.org/10.5012/jkcs.2011.55.4.656

Synthesis and Antibacterial Evaluation of Some Novel 1,3,4-oxadiazol Derivatives Incorporated with Quinoline Moiety  

Mandhane, Priyanka G. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Joshi, Ratnadeep S. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Khan, Wajid (Department of Microbiology, Maulana Azad College)
Gill, Charansingh H. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
Publication Information
Journal of the Korean Chemical Society / v.55, no.4, 2011 , pp. 656-661 More about this Journal
Abstract
5-(3,4,5-Triethoxyphenyl)-1,3,4-oxadiazole-2-thiol 6 on treatment with substituted 3-(bromomethyl)-2-chloroquinoline or 2-(p-tolyloxy)-3-(bromomethyl)quinoline 4a-j afforded the corresponding 3-((5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-ylthio)methyl)-2-chloroquinoline or 3-((5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-ylthio)methyl)-2-(p-tolyloxy)quinoline 7a-j, in the presence of $K_2CO_3$ and DMF under stirring at ambient temperature. All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against test organisms and reference standard.
Keywords
Gallic acid; 1,3,4-Oxadiazole; Quinoline-3-carbaldehyde; Antibacterial activity;
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