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http://dx.doi.org/10.5012/jkcs.2011.55.2.177

Synthesis of Diketo Copper(II) Complex and Its Binding toward Calf Thymus DNA (CTDNA)  

Tak, Aijaz Ahmad (Department of Chemistry, Islamia College of Science and Commerce Hawal Srinagar)
Arjmand, Farukh (A.M.U. Aligarh U.P. India)
Publication Information
Journal of the Korean Chemical Society / v.55, no.2, 2011 , pp. 177-182 More about this Journal
Abstract
A diketo-type ligand was synthesized by the Knoevenagel condensation reaction of thiophene-2-aldehyde with acetylacetone, subsequently its transition metal complexes with Cu(II), Ni(II), and Co(II) chlorides were also prepared. All the complexes were characterized by various physico-chemical methods. The molar conductivity data reveals ionic nature for the complexes. The electronic spectrum and the EPR values suggest square planar geometry for the Cu(II) ion. Interaction of the Cu(II) complex with CTDNA (calf thymus DNA) was studied by absorption spectral method and cyclic voltammetry. The $k_{obs}$ values versus [DNA] gave a linear plot suggesting psuedo-first order reaction kinetics. The cyclic voltammogram of the Cu(II) complex reveals a quasi-reversible wave attributed to Cu(II)/Cu(I) redox couple for one electron transfer with $E_{1/2}$ values -0.240 V and -0.194 V. respectively. On addition of CTDNA, there is a shift in the $E_{1/2}$ values 168 mV and 18 mV respectively and decrease in Ep values. The shift in $E_{1/2}$ values in the presence of CTDNA suggests strong binding of Cu(II) complex to the CTDNA.
Keywords
CTDNA; Redox potential; Copper(II) complex; Hypochromicity; Rate constant;
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