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http://dx.doi.org/10.5012/jkcs.2010.54.5.506

Synthesis, Characterization and Biological Activity of Some Complexes of Some New Amino Acid Derivatives N-[(Benzoyl amino)-Thioxomethyl]-Amino Acid(HL)  

Al-Mudhaffar, Dhafir M.H. (Chemistry Department, Science College, Basra University)
Al-Edani, Dawood S. (Chemistry Department, Science College, Basra University)
Dawood, Suma M. (Chemistry Department, Science College, Basra University)
Publication Information
Journal of the Korean Chemical Society / v.54, no.5, 2010 , pp. 506-514 More about this Journal
Abstract
A new series of ligands N-[(benzoylamino)-thioxomethyl]-amino acid (HL) were synthesized by reaction of benzoylisothiocyanate with various amino acids namely aspartic acid [BATA] (1), glutamic acid [BATG] (2), methionine [BATM] (3), leucine [BATL] (4), and tryptophan [BATT] (5). The ligands were characterized by elemental analysis, IR and NMR spectra. Some transition metal complexes ($ML_2$) for these ligands (6-8) were prepared; [M=Cu(II), Co(II), or Ni(II)], and characterized by elemental analysis, IR and $^1H$ NMR spectra. Antibacterial study showed that all the ligands have no antibacterial activity, whereas ($ML_2$) complexes; [M = Cu(II), Co(II), or Ni(II)] have antibacterial activity towards (Gram -ive) Escherichia (NCTC5933) and (Gram +ive) Staphylococcus (NCTC6571) and have no toxicity on (BALB/C) Albino mice.
Keywords
Ligands; Amino acid; Benzoylisothiocyanate; Transition metals; Antibacterial activity;
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