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http://dx.doi.org/10.5012/jkcs.2010.54.01.065

Isolation of Alkaloids with Immune Stimulating Activity from Oryza sativa cv. Heugnambyeo  

Ryu, Min-Ju (Department of Food and Nutrition, College of Natural Sciences, Duksung Women's University)
Chung, Ha-Sook (Department of Food and Nutrition, College of Natural Sciences, Duksung Women's University)
Publication Information
Journal of the Korean Chemical Society / v.54, no.1, 2010 , pp. 65-70 More about this Journal
Abstract
We describe the immune stimulatory effects of compounds determined by means of activity-monitored extraction and isolation techniques. As a result, 4-carboethoxy-6-methoxy-2-quinolone (1) and 4-carboethoxy-6-hydroxy-2-quinolone (2) were isolated from the ethyl acetate-soluble fraction of the Oryza sativa cv. Heugnambyeo bran, and were determined to exert significant inhibitory effects in macrophage cell line (murine RAW 264.7) and murine splenocytes. The structures were elucidated on the basis of spectroscopic evidence, particularly the results obtained via hetero nuclear multiple-bond connectivity and high-resolution MS spectroscopy. Up to date, compound (1) was isolated as natural sources for the first time.
Keywords
Oryza sativa cv. Heugnambyeo; Purple rice; Alkaloid; Immune stimulatory effect; Health-enhancing rice;
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