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http://dx.doi.org/10.5012/jkcs.2009.53.4.422

Practical and Green Approach for N-Boc Protection of Amines Catalyzed by Indion 190 Resin  

Chaskar, Atul (Department of Chemistry, Post graduate and Research centre, C. K. Thakur College,Dipartimento Di Chimica,Materiali Ed Ingegneria Chimica "Giulio Natta" Politecnico Di Milano)
Yewale, Sampat (Department of Chemistry, Post graduate and Research centre, C. K. Thakur College)
Langi, Bhushan (Department of Chemistry, Post graduate and Research centre, C. K. Thakur College)
Deokar, Hrushikesh (Department of Chemistry, Post graduate and Research centre, C. K. Thakur College)
Publication Information
Journal of the Korean Chemical Society / v.53, no.4, 2009 , pp. 422-426 More about this Journal
Abstract
An efficient, chemoselective and practical protocol for N-Boc protection of amines using di-tertbutoxypyrocarbonate $(Boc)_{2}O$ in presence of Indion 190 resin. Resin was easily separated from the reaction mixture by filtration and reused in subsequent reactions without any apparent loss of activity. Simple workup, mild condition, short reaction time and high yield are some of the striking features of the present process.
Keywords
Amines; Indion 190 resin; Di-tert-butoxypyrocarbonate $(Boc)_{2}O$; Chemoselectivity;
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