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http://dx.doi.org/10.5012/jkcs.2009.53.1.017

Synthesis, Physico-Chemical and Biological Properties of Complexes of Cobalt(II) Derived from Hydrazones of Isonicotinic Acid Hydrazide  

Prasad, Surendra (School of Chemical Sciences, Faculty of Science and Technology, The University of South Pacific)
Agarwal, Ram K. (School of Chemical Sciences, Faculty of Science and Technology, The University of South Pacific)
Publication Information
Journal of the Korean Chemical Society / v.53, no.1, 2009 , pp. 17-26 More about this Journal
Abstract
Hydrazones of isonicotinic acid hydrazide, viz., N-isonicotinamido-furfuralaldimine (INH-FFL), N-isonicotnamido-cinnamalidine (INH-CIN) and N-isonicotnamido-3',4',5'-trimethoxybenzaldimine (INH-TMB) were prepared by reacting isonicotinic acid hydrazide with respective aromatic aldehydes, i.e., furfural, cinnamaldehyde or 3,4,5-trimethoxy-benzaldehyde. A new series of fifteen complexes of cobalt(II) with these new hydrazones, INH-FFL, INH-CIN and INH-TMB, were synthesized by their reaction with cobalt(II) salts. The infrared spectral data reveal that hydrazone ligands behave as a bidentate ligand with N, O donor sequence towards the $Co^{2+}$ ion. The complexes were characterized on the basis of elemental analysis, magnetic susceptibility, conductivity, infrared and electronic spectral measurements. Analytical data reveal that the complexes have general composition [Co($L)_2X_2]\;and\;[Co(L)_3](ClO_4)_2$ where L= INH-FFL, INH-CIN or INH-TMB and X = $Cl^-,{NO_3}-,\;NCS^-\;or\;CH_3COO^-.$ The thermal behaviour of the complexes were studied using thermogravimetrictechnique. Electronic spectral results and magnetic susceptibility measurements are consistent with the adoption of a six-coordinate geometry for the cobalt(II) chelates. The antimicrobial properties of cobalt(II) complexes and few standard drugs have revealed that the complexes have very moderate antibacterial activities.
Keywords
Cobalt(II); Complexes; Hydrazones; Characterization; Biological activity;
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1 Burmeister, J.L. Coord. Chem. Rev. 1966, 3, 225.   DOI   ScienceOn
2 Burmeister, J.L. Coord. Chem. Rev. 1990, 105, 77.   DOI
3 Thomas, J.; Parameshwaram, G. Asian J. Chem. 2002, 14, 1370.
4 Ahuja, I.S.; Yadava, C.L.; Tripathi, S. Asian J. Chem. 1989, 1, 195   DOI
5 Thomas, J.; Parameshwaram, G. Asian J. Chem. 2002, 14, 1354
6 Lever, A.B.P. J. Chem. Edu. 1968, 45, 711   DOI
7 Reedijk, J.; Driesen, W.L.; Groenveld, W.L. Recl. Trav. Chim. 1968 ,88, 1095
8 Agarwal, R. K.; Sarin, R. K. Polyhedron 1993, 12, 2411   DOI   ScienceOn
9 Kurz, E.; Kober, G.; Berl, M. Anal. Chem. 1958, 30, 1983   DOI
10 Agarwal, R. K.; Srivastava, A. K.; Srivastava, M. Polish J. Chem. 1984, 53, 393
11 Agarwal, R. K.; Dutt, P.; Prakash, J. Polish J. Chem. 1992, 66, 899
12 Agarwal, R. K.; Sarin, R. K.; Agarwal, H. Bull. Chem. Soc. Ethio. 1995, 9, 23
13 Krishnan, P.S. R.; Indrasenan, P. Indian J. Chem. 1989, 28A 234
14 Agarwal, R. K.; Prakash, J. Polyhedron 1991, 10, 2399   DOI   ScienceOn
15 Burns, G.R. Inorg. Chem. 1968, 7, 272
16 Nakamoto, K. Infrared Spectra of Inorganic and Coordination Compounds, Willey, New York, 1970
17 Bailey, R.A.; Michelson, T.W.; Mills, W.N. J. Inorg. Nucl. Chem. 1971, 33, 3206   DOI   ScienceOn
18 Sharma, R.P.; Kothari, A.K.; Sharma, N.K. Ind. J. Derm. Vener. Lepr. 1995, 61, 261
19 Bassett, J.; Denney, R.C.; Jeffery, G.H.; Mendham, J. Vogel's Text Book of Quantitative Inorganic Analysis, 4th Ed., Longman Sc. Tech. Pub., London, 1986
20 Burmeister, J.L. Coord. Chem. Rev. 1966, 1, 205.
21 Bailey, R.A.; Kozak, S.L.; Michelson, T.W.; Mills, W.N. Coord. Chem. Rev. 1971, 6, 407   DOI
22 Addison, C.C.; Legan, N. Quart. Chem. Rev. 1971, 25, 289   DOI
23 Lever, A.B.P.; Mantiovane, E.; Ramaswamy, B.S. Canad. J. Chem. 1971, 49, 1957   DOI
24 Agarwal, R. K.; Prakash, B. Trans. Metal Chem. 2005, 30, 696   DOI
25 Agarwal, R. K.; Singh, L.; Sharma, D.K.; Singh, R. Turk. J. Chem. 2005, 29, 309
26 Tumer, M.; Deligonul, N.; Golcu, A.; Akgun, E.; Dolaz, M. Trans. Metal Chem. 2006, 31, 1   DOI
27 Agarwal, R. K.; Sharma, S.K. Polish J. Chem. 1993, 67, 581
28 Murukan, B.; Mohanan, K. Trans. Metal Chem. 2006, 31, 441   DOI
29 Tumer, M.; Ekinci, D.; Tumer, F.; Bulut, A. Spectrochim. Acta A: Mol. Biomol. Spectrosc. 2007, 66, 1271   DOI   ScienceOn
30 Pandey, G.; Narang, K.K. Bioinorg. Chem. Appl. 2005, 3, 217   DOI   ScienceOn
31 Sharaby, C.M. Spectrochim. Acta A: Mol. Biomol. Spectrosc. 2007, 66, 1271   DOI   ScienceOn
32 Mohamed, G.C.; Sharaby, C.M. Spectrochim. Acta A: Mol. Biomol. Spectrosc. 2007, 66, 949   DOI   ScienceOn
33 Ashok, M.; Prasad, A.V.S.S.; Ravinder, V. J. Braz. Chem. Soc. 2007, 26, 204
34 Ferrari, M.B.; Fava, G.G.; Leporti, E.; Pelosi, G.; Tarasconi, P.; Albertini, R.; Bonati, A.; Lunghi, P.; Pineli, S. J. Inorg. Biochem. 1998, 70, 145   DOI   ScienceOn
35 Srivastava, A.K.; Pandey, O.P.; Sengupta, S.K. Bioinorg. Chem. Appl. 2005, 3, 289   DOI   ScienceOn
36 Chandra, S.; Kumar, A. Spectrochim. Acta A: Mol. Biomol. Spectrosc. 2007, 66, 1347   DOI   ScienceOn
37 Kilpin, K.J.; Henderson, W.; Nicholson, B.K. Polyhedran 2007, 26, 204   DOI   ScienceOn
38 Prasad,S; Agarwal, R. K. Res. Lett. Inorg Chem., 2008, 1, 1
39 Prasad, S; Agarwal, R.K. Trans. Metal Chem. 2007, 32, 143 and refs. cited therein   DOI
40 Agarwal, R. K.; Prasad, S. Bioinorg. Chem. Appl. 2005, 3, 271 and refs. cited therein   DOI   ScienceOn
41 Agarwal, R. K.; Prasad, S.; Gahlot, N. Turk. J. Chem. 2004, 28, 691
42 Agarwal, R. K.; Prasad, S. Revs. Inorg. Chem. 2006, 26, 471
43 Agarwal, R. K.; Prasad, S. Turkish J. Chem. 2005, 29, 289