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http://dx.doi.org/10.5012/jkcs.2008.52.2.118

The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy  

Lee, Chul-Jae (School of Applied Chemical Engineering, Sangju National University)
Jung, Maeng-Joon (School of Applied Chemical Engineering, Sangju National University)
Publication Information
Journal of the Korean Chemical Society / v.52, no.2, 2008 , pp. 118-123 More about this Journal
Abstract
The interaction of the antitumour agent, doxorubicin, with adenine is investigated in an aqueous solution at a concentration of 10-3~10-4 with volume ratios of 1:2. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the binding sites of doxorubicin to adenine and the structural variations of doxorubicin-adenine complexes in an aqueous solution. We identified that the possibilities of doxorubicin interacted with the N7 positions of adenine.
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