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http://dx.doi.org/10.5012/jkcs.2008.52.1.036

Synthesis, Reaction and Antiviral Activity of 2,4-Diaryl-1,3-selenazoles  

Al-Rubaie, Ali Z. (Department of Chemistry, College of Science, University of Basrah)
Al-Masoudi, Wasfi A. (Department of Chemistry, College of Arts and Science, Al-Mergab University)
Hameed, Ali Jameel (Department of Chemistry, College of Science, University of Basrah)
Yousif, Lina Z. (Department of Chemistry, College of Science, University of Basrah)
Graia, Mohsen (Laboratoire de Mate et Cristallochimie, Faculte des Sciences de Tunis)
Publication Information
Journal of the Korean Chemical Society / v.52, no.1, 2008 , pp. 36-46 More about this Journal
Abstract
cyclization of primary arylselenocarboxylic amides with a-bromoketones afforded a variety of new 2,4-diaryl-1,3-selenazoles. Halogenation of the 2,4-diaryl-1,3-selenazoles with chlorine, bromine and iodine gave the new 1,1-dihalo-2,4-diaryl-1,3-selenazoles in good yields. Antiviral activity of some 1,1-dihalo-2,4-diaryl-1,3-selenazoles has been tested against AIDS virus (HIV-1 and HIV-2). They showed some bioactivity against HIV-1. All compounds were characterized by their elemental analysis, 1H NMR and mass spectroscopic data. The crystal structure of 2-(3,4-dimethoxyphenyl)-4-(4-bromophenyl)-1,3-selenazole displays the molecular configuration.
Keywords
1,3-Selenazoles; arylselenocarboxamides; α-bromoketones; X-ray; HIV-1
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