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http://dx.doi.org/10.5012/jkcs.2006.50.6.464

Preparation of the Dexamethasone-incorporated Lipid Nanosphere: Characteristics of Lipid Nanosphere by Varying Species and Ratio of Lipid  

Jeong, Seok-Hyeon (한국화학연구원)
Lee, Jeong-Eun (한국화학연구원)
Seong, Ha-Su (한국화학연구원)
Sin, Byeong-Cheol (한국화학연구원)
Publication Information
Journal of the Korean Chemical Society / v.50, no.6, 2006 , pp. 464-470 More about this Journal
Abstract
the coricosteroid drug dexamethasone is an efficacious antiinflammatory drug, it is difficult to formulate in an injectable formulation due to its poor aqueous solubility. A lipid-based nanosphere formulation containing dexamethasone was designed for solubilization of the drug in aqueous solution and sustained release of the drug from the nanosphere. The lipid nanospheres, composed of phospholipid, cholesterol and cationic lipid, were prepared by self emulsification-solvent diffusion method followed by diafiltration. Physicochemical characteristics such as mean particle diameter, zeta potential and drug loading efficiency of the lipid nanospheres were investigated according to the variation of either the kind of lipid or the lipid composition. The lipid nanospheres had a mean diameter 80-120 nm and dexamethasone loading efficiency of greater than 80%. The drug loading efficiency increased with the increase of the length of aliphatic chain attached to the phospholipid. However, the drug loading efficiency was inversely proportional to the increase of cholesterol content in the lipid composition. The lipid nanosphere could not be prepared without the use of cationic lipid and the drug loading efficiency was proportional to the increase of cationic lipid content. The lipid nanospheres containing dexamethasone are a promising novel drug carrier for an injectable formulation of the poorly water-soluble drugs.
Keywords
Lipid Nanosphere; Spontaneous Emulsification-solvent Diffusion; Poorly Water-soluble Drug; Dexamethasone
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1 Mohammed, A. R.; Weston, N.; Coombes, A. G. A.; Fitzgerald, M.; Perrie, Y. Int. J. Pharm., 2004, 285, 23-34   DOI   ScienceOn
2 Sanchez, A.; Vila-Jato, J. L.; Alonso, M. J. Int. J. Pharm., 1993, 99, 263-267   DOI   ScienceOn
3 Tauchi, Y.; Takase, M.; Zushida, I.; Chono, S.; Sato, J.; Ito, K.; Morimoto, K. J. Pharm. Sci., 1999, 88, 709-714   DOI
4 대한약전 제 7 개정, 대한보건공정서 협회, 제 1 부, 제 2 부, 71-72
5 Wissing, S. A.; Kayser, O.; Muller, R. H. Adv. Drug. Deliver. Rev., 2004, 56, 1257-1272   DOI   ScienceOn
6 McCormack, B.; Gregoriadis, G. Biochim. Biophys. Acta., 1996, 1291, 237-244   DOI   ScienceOn
7 Turkoglu, O. F.; Eroglu, H.; Okutan, O.; Burul, E.; Sargon, M. F.; Ozer, N.; Oner, L.; Beskonakli, E. Surg. Neurol., 2005, 64, S2:11-S2:16   DOI   ScienceOn
8 Seki, J.; Sonoke, S.; Saheki, A.; Fukui, H.; Sasaki, H.; Mayumi, T. Int. J. Pharm., 2004, 273, 75-83   DOI   ScienceOn
9 Murakami, H.; Kobayashi, M.; Takeuchi, H.; Kawashima, Y. Powder. Technol., 2000, 107, 137-143   DOI   ScienceOn
10 Song, C. X.; Labhasetwar, V.; Murphy, H.; Qu, X.; Humphrey, W. R.; Shebuski, R. J.; Levy, R. J. J. Control. Release., 1997, 43, 197-212   DOI   ScienceOn
11 Fukui, H.; Koike, T.; Saheki, A.; Sonoke, S.; Seki, J. Int. J. Pharm., 2003, 265, 37-45   DOI   ScienceOn
12 Niwa, T.; Takeuchi, H.; Hino, T.; Kunou, N.; Kawashima, Y. J. Control. Rel. 1993, 25, 89-98   DOI   ScienceOn
13 Hickey, T.; Kreutzer, D.; Burgess, D. J.; Moussy, F. Biomaterials., 2002, 23, 1649-1656   DOI   ScienceOn
14 Yokoyama, K.; Watanabe, M. Adv. Drug. Deliver. Rev., 1996, 20, 195-201   DOI   ScienceOn
15 Murakami, H.; Kobayashi, M.; Takeuchi, H.; Kawashima, Y. Int. J. Pharm., 1999, 187, 143-152   DOI   ScienceOn