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http://dx.doi.org/10.5012/jkcs.2006.50.2.123

Analysis of Interleukin-6 Gene Polymorphisms in Behcet’s Disease Using RFLP and DHPLC  

Jang, Won-Cheol (단국대학교)
Park, Sang-Beom (단국대학교)
Nam, Yun-Hyeong (단국대학교)
Lee, Jae-Sik (단국대학교)
Publication Information
Journal of the Korean Chemical Society / v.50, no.2, 2006 , pp. 123-128 More about this Journal
Abstract
Behcet's disease (BD) is a systemic vasculitis characterized by recurrent oral and genital ulcers, and ocular inflammation, and which may involve the joints, skin, central nervous system and gastrointestinal tract. Although the exact pathogenesis for BD is not completely understood, it has been suggested that the disease is triggered in genetically susceptible individuals by environmental factors, such as microbial agents. It is noted that multiple genes, including MHC (major histocompatibility complex) and non-MHC genes, are implicated in the pathogenesis of BD. This study tries to determine whether IL-6 gene polymorphisms are associated with susceptibility to Behcet's disease in Koreans. Gene polymorphisms were typed by VNTR (variable number of tandem repeat), RFLP (restriction fragment length polymorphism), DHPLC (denaturing high performance liquid chromatography).There were no evidences for genetic association conferred by the IL-6prom polymorphism. However, significant differences in the IL-6vntr genotype and allele frequencies were found between patients with BD and controls. The IL-6vntr*C allele appeared to be an additional susceptibility gene to Korean BD. Further studies in other populations and gene are required to confirm these results.
Keywords
BD(behcet's disease); IL-6; DHPLC; RFLP; VNTR
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