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http://dx.doi.org/10.5012/jkcs.2006.50.1.037

Analysis of Androgen Receptor Gene by Capillary Gel Eelectrophoresis  

Kim, Yong-Seong (경남대학교)
Baek, Seung-Gwon (경남대학교)
Gang, Chung-Mu (경남대학교)
Gang, Dae-Cheon (경남대학교)
Lee, Su-Man (포천중문의과대학교)
Choe, Byeong-Ok (이화여자대학교)
Jeong, Gi-Hwa (공주대학교)
Choe, Gyu-Seong (경남대학교)
Publication Information
Journal of the Korean Chemical Society / v.50, no.1, 2006 , pp. 37-45 More about this Journal
Abstract
gel electrophoresis (CGE) with poly(ethylene oxide) has been applied to the measurement of CAG repeat number in Androgen receptor (AR) gene related to male infertility. Non-linear regression analysis was performed using the standard X174 RF/Hae III, 100bp step ladder DNA in order to investigate the exact number of CAG repeat. For 79 Korean infertile males and 89 controls, CAG repeats at exon 1 in AR gene was compared and analyzed by CGE. It turned out that CAG repeat numbers were 24.972.6 range, 17-29) for the infertile male, and 23.992.4 range, 18-29) for the control, respectively. P value (0.018) was less then 0.05, meaning that the result was statistically meaningful.
Keywords
Capillary; Electrophoresis; CAG Repeat; Infertile
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