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http://dx.doi.org/10.5012/jkcs.2004.48.2.137

Analysis of 2-Mercapro-1-Methylimidazole in Controlling Drug of Thyroid by Differential Pulse Polarography  

Kim, Il-Kwang (Department of Chemistry, Institute of Basic Nature Science, College of Natural Science, Wonkwang University)
Chun, Hyun-Ja (Department of Chemistry, Institute of Basic Nature Science, College of Natural Science, Wonkwang University)
Han, Sung-Soo (Department of Agricultural Chemistry, College of Life Science and Natural Resourses, Wonkwang University)
Publication Information
Journal of the Korean Chemical Society / v.48, no.2, 2004 , pp. 137-143 More about this Journal
Abstract
The determination of 2-mercapto-1-methyl-imidazole (MMI) in 5.0${\times}10^{-2}$ M lithium perchlorate suporting electrolyte has been investigated by the differential pulse polarography. The optimum condition of MMI analysis was as follows; -0.9 volts initial potential, 0.08 mV pulse height, 2 mV/sec scan rate, and medium mercury drop size. Standard calibration curve showed a good linearlity in the range of 1.0${\times}10^{-7}M\;to\;8.0{\times}10^{-5}$ M and the detection limit has been (2.2${\pm}0.1){\times}0.1^{-9}$ M. This method was applicated for the determination of MMI in antithyroid drug without interference of additives.
Keywords
Antithyroid; 2-Mercapto-1-Methyl-imidazole; Differential Pulse Polarography;
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