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http://dx.doi.org/10.5012/jkcs.2002.46.2.151

Increased Anticancer Activity by the Surfated Funcoidan from Korean Brown Seaweeds  

Park, Jang-Su (Department of Chemistry Pusan National University)
Kim, An Deu Re (Department of Chemistry Pusan National University)
Kim, Eun-Hui (Department of Chemistry Pusan National University)
Seo, Hong-Suk (Department of Chemistry Pusan National University)
Choe, Won-Cheol (Department of Biology, Pusan National University)
Publication Information
Journal of the Korean Chemical Society / v.46, no.2, 2002 , pp. 151-156 More about this Journal
Abstract
Fucoidan is a kind of polysaccharides in brown seaweeds. For the past years have been extensively studied due to their numerous biological activities : anticancer, anticoagulant, antithrombotic, anti-inflammatory and antiviral. In this study, we h ave extracted fucoidan from the Korean brown seaweeds and examined it's anticancer activities for employed SV40 DNA replication assay, RPA-ssDNA binding assay of replication protein A(RPA: known as human single-stranded DNA-binding protein essential for DNA rep-lication) and MCF7 cell growth inhibition assay. In addition to, we found that chemically sulfated fucoidan'santicancer activity is more higher than natural and desulfated fucoidan. It seem that fucoidan's sulfate group affect on DNA replication, cause of decrease RPA's DNA binding activity. These results suggests that sulfated fucoidan from Korean brown seaweeds have anticancer activity.
Keywords
Sulfated fucoidan; anticancer; replication protein A(RPA); SV40 ENA replication;
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