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http://dx.doi.org/10.5012/bkcs.2014.35.8.2481

Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study  

Kadayat, Tara Man (College of Pharmacy, Yeungnam University)
Kim, Mi Jin (College of Pharmacy, Yeungnam University)
Nam, Tae-Gyu (Department of Pharmacy, Hanyang University)
Park, Pil-Hoon (College of Pharmacy, Yeungnam University)
Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.8, 2014 , pp. 2481-2486 More about this Journal
Abstract
Twelve thienyl/furanyl-hydroxyphenylpropenones were systematically designed and synthesized, and evaluated for their inhibitory effect on LPS-induced ROS and NO production in RAW 264.7 macrophages. Compound 11 displayed the most significant inhibitory activity of LPS-induced ROS and NO production in RAW 264.7 macrophages. Structure-activity relationship study indicated that para-hydroxyphenyl moiety plays an important role for inhibitory activities on both LPS-induced ROS and NO production as well as 3-thienyl moiety on molecule.
Keywords
Thieny/Furanyl-hydroxyphenylpropenones; LPS-induced ROS and NO; Inhibition; Structure-activity relationship study;
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