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http://dx.doi.org/10.5012/bkcs.2014.35.7.2038

Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines  

Che, Haiyan (College of Pharmacy, Kangwon National University)
Fang, Yuanying (College of Pharmacy, Kangwon National University)
Gurung, Santosh K. (College of Pharmacy, Kangwon National University)
Luo, Jun (College of Pharmacy, Kangwon National University)
Yoon, Deok Hyo (College of Natural Science (Biochemistry), Kangwon National University)
Sung, Gi-Ho (Rural Development Administration)
Kim, Tae Woong (College of Natural Science (Biochemistry), Kangwon National University)
Park, Haeil (College of Pharmacy, Kangwon National University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.7, 2014 , pp. 2038-2042 More about this Journal
Abstract
4-(tert-Octyl)phenol derivatives bearing the D-mannitol substructure (6a, 6b, 7) were prepared from $\small{D}$-mannitol and evaluated their anticancer activity against human lung (A549) and prostate (Lncap, Du145, PC3) cancer cell lines. Among derivatives tested, the bis(tert-octyl)phenoxy compound 7 exhibited strongest proliferation inhibitory activities against human cancer cell lines tested, especially high sensitivity to human Du145 prostate cancer cells ($IC_{50}=7.3{\mu}M$).
Keywords
Cordyceps militaris; Militarin; 4-(tert-Octyl)phenol derivatives; D-Mannitol substructure; Anticancer activity;
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