[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2014.35.7.1970

A Facile and Efficient Synthesis of Dronedarone Hydrochloride

Li, Feng (School of Biological & Chemical Engineering, Ningbo Institute of Technology, Zhejiang University)
Jin, Chunhua (School of Biological & Chemical Engineering, Ningbo Institute of Technology, Zhejiang University)
Zou, Jianwei (School of Biological & Chemical Engineering, Ningbo Institute of Technology, Zhejiang University)
Wu, Jun (Department of Chemistry, Zhejiang University)

Publication Information

Bulletin of the Korean Chemical Society / v.35, no.7, 2014 , pp. 1970-1972 More about this Journal

Abstract

A facile and efficient synthesis of dronedarone hydrochloride starting from commercially available 4-nitrophenol is described. This approach features a tandem-type synthesis of 3-carbonylated benzofuran involving cyclization of 2-ethynylphenol followed by $CO_2$ fixation at the 3-position of the benzofuran ring mediated by potassium carbonate without the addition of any transition metal catalyst.

Keywords

Dronedarone; Tandem-type synthesis; Cyclization; $CO_2$ fixation;

Citations & Related Records

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