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http://dx.doi.org/10.5012/bkcs.2014.35.6.1759

Chiral 2-Amino Alcohol Derivatives Catalyze the Enantioselective α-Chlorination of β-Ketoesters  

Zhang, Baohua (College of Chemical Engineering, Shijiazhuang University)
Guo, Ruixia (College of Chemical Engineering, Shijiazhuang University)
Liu, Sijie (College of Chemical Engineering, Shijiazhuang University)
Shi, Lanxiang (College of Chemical Engineering, Shijiazhuang University)
Li, Xiaoyun (College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.6, 2014 , pp. 1759-1762 More about this Journal
Abstract
The enantioselective ${\alpha}$-chlorination of cyclic ${\beta}$-ketoesters catalyzed by chiral 2-aminoalcohol derivatives (2f) has been developed. For the optically active ${\alpha}$-chlorinated products, the isolated yields are in the range of 85-94% and the enantiomeric excesses are up to 84% ee.
Keywords
Enantioselective ${\alpha}$-chlorination; 2-Aminoalcohol derivatives; ${\beta}$-Ketoesters;
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