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http://dx.doi.org/10.5012/bkcs.2014.35.1.158

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients  

Han, Hyojeong (Molecular Recognition Research Center, Korea Institute of Science and Technology)
Seo, Hong Seog (Division of Cardiology, Korea University College of Medicine)
Jung, Byung Hwa (Molecular Recognition Research Center, Korea Institute of Science and Technology)
Woo, Kyoungja (Molecular Recognition Research Center, Korea Institute of Science and Technology)
Yoo, Young Sook (Molecular Recognition Research Center, Korea Institute of Science and Technology)
Kang, Min-Jung (Molecular Recognition Research Center, Korea Institute of Science and Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.1, 2014 , pp. 158-164 More about this Journal
Abstract
Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.
Keywords
Substance P; Neuropeptide Y; Biomarker; Acute myocardial infarction; LC-MS;
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