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http://dx.doi.org/10.5012/bkcs.2014.35.12.3489

Synthesis of Dithiolopyrrolone Derivatives and Their Leukocyte-Increasing Activities  

Li, Chungang (Shanghai Institute of Pharmaceutical Industry, State Institute of Pharmaceutical Industry)
Sun, Yiping (Shanghai Shyndec Pharmaceutical Co., Ltd)
Wang, Guoping (Shanghai Institute of Pharmaceutical Industry, State Institute of Pharmaceutical Industry)
Tan, Xiangduan (College of pharmacy, Guilin Medical University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.12, 2014 , pp. 3489-3494 More about this Journal
Abstract
In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds 4, 9 and 16 had a moderate effect ( p < 0.05). Compound 5 also displayed stronger leukocyte-increasing activity than that of the positive recombinant human granulocyte colony stimulating factor (rhG-CSF). Above all, compound 5 would be a potential antileukopenia agent which deserved further research.
Keywords
Dithiolopyrrolone derivatives; Leukocyte-increasing activity; Leukopenia; Antileukopenia; rhG-CSF;
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