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http://dx.doi.org/10.5012/bkcs.2014.35.10.3009

C-H Arylation of Nitroimidazoles and Nitropyrazoles Guided by the Electronic Effect of the Nitro Group  

Jung, Haeun (Department of Chemistry, Pusan National University)
Bae, Seri (Department of Chemistry, Pusan National University)
Jang, Ha-Lim (Department of Chemistry, Pusan National University)
Joo, Jung Min (Department of Chemistry, Pusan National University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.10, 2014 , pp. 3009-3014 More about this Journal
Abstract
A palladium-catalyzed C-H arylation reaction of nitroimidazoles and nitropyrazoles was developed using aryl bromides as arene donors. The electron-withdrawing effect of the nitro group allows for direct C-H arylation reactions of the nitro diazoles with high regioselectivity under mild conditions. The new C-H arylation approach is thus complementary to nucleophilic substitution reactions, enabling the preparation of complex nitroazole compounds.
Keywords
C-H arylation; Nitroimidazole; Nitropyrazole; Palladium;
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