Browse > Article
http://dx.doi.org/10.5012/bkcs.2014.35.10.2955

Ginsenosides Inhibit HMGB1-induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis  

Lee, Wonhwa (BK21 Plus KNU Biomedical Convergence Program, Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University)
Ku, Sae-Kwang (Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University)
Jeong, Tae Cheon (College of Pharmacy, Yeungnam University)
Lee, Sangkyu (College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
Bae, Jong-Sup (College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.10, 2014 , pp. 2955-2962 More about this Journal
Abstract
Asian ginseng is used as a treatment for cardiovascular diseases, ischemia, and cancers. High mobility group box 1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions. However, the effect of ginsenosides from Asian ginseng on HMGB1-induced inflammatory responses has not been studied. We addressed this question by monitoring the effects of ginsenoside treatment on lipopolysaccharide (LPS) and cecal ligation and puncture (CLP)-mediated release of HMGB1, and HMGB1-mediated regulation of proinflammatory responses. Ginsenoside treatment suppressed LPS-mediated release of HMGB1 and HMGB1-mediated cytoskeletal rearrangements. Ginsenosides also inhibited HMGB1-mediated inflammatory responses. In addition, ginsenosides inhibited the production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and activation of protein kinase B (Akt), nuclear factor-${\kappa}B$ (NF-${\kappa}B$), and extracellular-regulated kinases (ERK) 1/2 by HMGB1. Ginsenosides also decreased CLP-induced release of HMGB1, production of interleukin (IL) $1{\beta}/6$, and mortality. These results suggested that ginsenosides may be potential therapeutic agents for treatment of vascular inflammatory diseases through inhibition of the HMGB1 signaling pathway.
Keywords
Ginsenosides; HMGB1; Vascular inflammation; Sepsis;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Wang, H.; Zhu, S.; Zhou, R.; Li, W.; Sama, A. E. Expert. Rev. Mol. Med. 2008, 10, e32.   DOI
2 Martin, G. S.; Mannino, D. M.; Eaton, S.; Moss, M. N Engl. J. Med. 2003, 348, 1546.   DOI   ScienceOn
3 Williams, S. C. Nat. Med. 2012, 18, 1001.   DOI
4 Wang, H.; Yang, H.; Tracey, K. J. J. Intern. Med. 2004, 255, 320.   DOI   ScienceOn
5 Takeuchi, O.; Akira, S. Int. Immunopharmacol. 2001, 1, 625.   DOI   ScienceOn
6 Andersson, U.; Wang, H.; Palmblad, K.; Aveberger, A. C.; Bloom, O.; Erlandsson-Harris, H.; Janson, A.; Kokkola, R.; Zhang, M.; Yang, H.; Tracey, K. J. J. Exp. Med. 2000, 192, 565.   DOI   ScienceOn
7 Lotze, M. T.; Tracey, K. J. Nat. Rev. Immunol. 2005, 5, 331.   DOI   ScienceOn
8 Yang, R.; Harada, T.; Mollen, K. P.; Prince, J. M.; Levy, R. M.; Englert, J. A.; Gallowitsch-Puerta, M.; Yang, L.; Yang, H.; Tracey, K. J.; Harbrecht, B. G.; Billiar, T. R.; Fink, M. P. Mol. Med. 2006, 12, 105.
9 Bae, J. S. Arch. Pharm. Res. 2012, 35, 1511.   DOI   ScienceOn
10 Hori, O.; Brett, J.; Slattery, T.; Cao, R.; Zhang, J.; Chen, J. X.; Nagashima, M.; Lundh, E. R.; Vijay, S.; Nitecki, D.; et al. J. Biol. Chem. 1995, 270, 25752.   DOI   ScienceOn
11 Park, J. S.; Svetkauskaite, D.; He, Q.; Kim, J. Y.; Strassheim, D.; Ishizaka, A.; Abraham, E. J. Biol. Chem. 2004, 279, 7370.   DOI   ScienceOn
12 Chan, R. Y.; Chen, W. F.; Dong, A.; Guo, D.; Wong, M. S. J. Clin. Endocrinol. Metab. 2002, 87, 3691.   DOI
13 Andersson, U.; Tracey, K. J. Annu. Rev. Immunol. 2011, 29, 139.   DOI   ScienceOn
14 Cui, J. F.; Garle, M.; Lund, E.; Bjorkhem, I.; Eneroth, P. Anal. Biochem. 1993, 210, 411.   DOI   ScienceOn
15 Attele, A. S.; Wu, J. A.; Yuan, C. S. Biochem. Pharmacol. 1999, 58, 1685.   DOI   ScienceOn
16 Morisaki, N.; Watanabe, S.; Tezuka, M.; Zenibayashi, M.; Shiina, R.; Koyama, N.; Kanzaki, T.; Saito, Y. Br. J. Pharmacol. 1995, 115, 1188.   DOI   ScienceOn
17 Lee, Y. J.; Jin, Y. R.; Lim, W. C.; Park, W. K.; Cho, J. Y.; Jang, S.; Lee, S. K. Arch. Pharm. Res. 2003, 26, 58.   DOI
18 Korivi, M.; Hou, C. W.; Huang, C. Y.; Lee, S. D.; Hsu, M. F.; Yu, S. H.; Chen, C. Y.; Liu, Y. Y.; Kuo, C. H. Evid Based Complement. Alternat. Med. 2012, 2012, 932165.
19 Zhang, G.; Liu, A.; Zhou, Y.; San, X.; Jin, T.; Jin, Y. J. Ethnopharmacol. 2008, 115, 441.   DOI   ScienceOn
20 Chen, G.; Ward, M. F.; Sama, A. E.; Wang, H. J. Interferon Cytokine Res. 2004, 24, 329.   DOI
21 Yang, H.; Tracey, K. J. Biochim. Biophys. Acta 2010, 1799, 149.   DOI
22 Yang, H.; Wang, H.; Czura, C. J.; Tracey, K. J. J. Leukoc. Biol. 2005, 78, 1.   DOI   ScienceOn
23 Bae, J. S.; Rezaie, A. R. Thromb. Haemost. 2008, 100, 101.
24 Lee, W.; Yang, E. J.; Ku, S. K.; Song, K. S.; Bae, J. S. BMB Rep. 2012, 45, 390.   DOI   ScienceOn
25 Kim, T. H.; Ku, S. K.; Lee, I. C.; Bae, J. S. BMB Rep. 2012, 45, 200.   DOI   ScienceOn
26 Kim, T. H.; Bae, J. S. Food Chem. Toxicol. 2010, 48, 1682.   DOI   ScienceOn
27 Lee, W.; Kim, T. H.; Ku, S. K.; Min, K. J.; Lee, H. S.; Kwon, T. K.; Bae, J. S. Toxicol. Appl. Pharmacol. 2012, 262, 91.   DOI   ScienceOn
28 Che, W.; Lerner-Marmarosh, N.; Huang, Q.; Osawa, M.; Ohta, S.; Yoshizumi, M.; Glassman, M.; Lee, J. D.; Yan, C.; Berk, B. C.; Abe, J. Circ. Res. 2002, 90, 1222.   DOI   ScienceOn
29 Bae, J. S.; Rezaie, A. R. Blood 2011, 118, 3952.   DOI   ScienceOn
30 Bae, J. S.; Lee, W.; Rezaie, A. R. J. Thromb. Haemost. 2012.
31 Lee, J. D.; Huh, J. E.; Jeon, G.; Yang, H. R.; Woo, H. S.; Choi, D. Y.; Park, D. S. Int. Immunopharmacol. 2009, 9, 268.   DOI   ScienceOn
32 Akeson, A. L.; Woods, C. W. J. Immunol. Methods 1993, 163, 181.   DOI   ScienceOn
33 Buras, J. A.; Holzmann, B.; Sitkovsky, M. Nat. Rev. Drug. Discov. 2005, 4, 854.   DOI   ScienceOn
34 Wang, H.; Liao, H.; Ochani, M.; Justiniani, M.; Lin, X.; Yang, L.; Al-Abed, Y.; Metz, C.; Miller, E. J.; Tracey, K. J.; Ulloa, L. Nat. Med. 2004, 10, 1216.   DOI   ScienceOn
35 El Gazzar, M. Inflamm. Res. 2007, 56, 162.   DOI
36 Mullins, G. E.; Sunden-Cullberg, J.; Johansson, A. S.; Rouhiainen, A.; Erlandsson-Harris, H.; Yang, H.; Tracey, K. J.; Rauvala, H.; Palmblad, J.; Andersson, J.; Treutiger, C. J. Scand J. Immunol. 2004, 60, 566.   DOI   ScienceOn
37 Sama, A. E.; D'Amore, J.; Ward, M. F.; Chen, G.; Wang, H. Acad. Emerg. Med. 2004, 11, 867.
38 Qin, Y. H.; Dai, S. M.; Tang, G. S.; Zhang, J.; Ren, D.; Wang, Z. W.; Shen, Q. J. Immunol. 2009, 183, 6244.   DOI   ScienceOn
39 Berman, R. S.; Frew, J. D.; Martin, W. Br. J. Pharmacol. 1993, 110, 1282.   DOI   ScienceOn
40 Goldblum, S. E.; Ding, X.; Brann, T. W.; Campbell-Washington, J. J. Cell Physiol. 1993, 157, 13.   DOI   ScienceOn
41 Wolfson, R. K.; Chiang, E. T.; Garcia, J. G. Microvasc. Res. 2011, 81, 189.   DOI   ScienceOn
42 Schnittler, H. J.; Schneider, S. W.; Raifer, H.; Luo, F.; Dieterich, P.; Just, I.; Aktories, K. Pflugers Arch. 2001, 442, 675.   DOI
43 Friedl, J.; Puhlmann, M.; Bartlett, D. L.; Libutti, S. K.; Turner, E. N.; Gnant, M. F.; Alexander, H. R. Blood 2002, 100, 1334.
44 Wang, F. P.; Li, L.; Li, J.; Wang, J. Y.; Wang, L. Y.; Jiang, W. PLoS One 2013, 8, e64373.   DOI
45 Petrache, I.; Birukova, A.; Ramirez, S. I.; Garcia, J. G.; Verin, A. D. Am J. Respir Cell Mol. Biol. 2003, 28, 574.   DOI
46 Hansson, G. K.; Libby, P. Nat. Rev. Immunol. 2006, 6, 508.   DOI   ScienceOn
47 Kawahara, K.; Hashiguchi, T.; Kikuchi, K.; Tancharoen, S.; Miura, N.; Ito, T.; Oyama, Y.; Nawa, Y.; Biswas, K. K.; Meng, X.; Morimoto, Y.; Shrestha, B.; Sameshima, H.; Maruyama, I. Int. J. Mol. Med. 2008, 22, 639.
48 Lockyer, J. M.; Colladay, J. S.; Alperin-Lea, W. L.; Hammond, T.; Buda, A. J. Circ. Res. 1998, 82, 314.   DOI   ScienceOn
49 Palumbo, R.; Galvez, B. G.; Pusterla, T.; De Marchis, F.; Cossu, G.; Marcu, K. B.; Bianchi, M. E. J. Cell Biol. 2007, 179, 33.   DOI   ScienceOn
50 Marui, N.; Offermann, M. K.; Swerlick, R.; Kunsch, C.; Rosen, C. A.; Ahmad, M.; Alexander, R. W.; Medford, R. M. J. Clin. Invest. 1993, 92, 1866.   DOI   ScienceOn
51 Rose, B. A.; Force, T.; Wang, Y. Physiol. Rev. 2010, 90, 1507.   DOI
52 Cohen, J. Nature 2002, 420, 885.   DOI   ScienceOn
53 Teiten, M. H.; Eifes, S.; Dicato, M.; Diederich, M. Toxins (Basel) 2010, 2, 128.   DOI
54 Xiao, H.; Siddiqui, J.; Remick, D. G. Infect. Immun. 2006, 74, 5227.   DOI
55 Bhatia, M.; He, M.; Zhang, H.; Moochhala, S. Front Biosci. 2009, 14, 4703.
56 Karlsson, S.; Pettila, V.; Tenhunen, J.; Laru-Sompa, R.; Hynninen, M.; Ruokonen, E. Intensive Care Med. 2008, 34, 1046.   DOI
57 Tung, N. H.; Song, G. Y.; Park, Y. J.; Kim, Y. H. Chem. Pharm. Bull. (Tokyo) 2009, 57, 1412.   DOI   ScienceOn
58 Tracey, K. J.; Fong, Y.; Hesse, D. G.; Manogue, K. R.; Lee, A. T.; Kuo, G. C.; Lowry, S. F.; Cerami, A. Nature 1987, 330, 662.   DOI   ScienceOn
59 Wichterman, K. A.; Baue, A. E.; Chaudry, I. H. J. Surg. Res. 1980, 29, 189.   DOI   ScienceOn
60 Wang, H.; Yang, H.; Czura, C. J.; Sama, A. E.; Tracey, K. J. Am J. Respir Crit. Care Med. 2001, 164, 1768.   DOI   ScienceOn
61 Angus, D. C.; Yang, L.; Kong, L.; Kellum, J. A.; Delude, R. L.; Tracey, K. J.; Weissfeld, L. Crit. Care. Med. 2007, 35, 1061.   DOI
62 Valerio, D. A.; Cunha, T. M.; Arakawa, N. S.; Lemos, H. P.; Da Costa, F. B.; Parada, C. A.; Ferreira, S. H.; Cunha, F. Q.; Verri, W. A., Jr. Eur. J. Pharmacol. 2007, 562, 155.   DOI
63 Sun, C.; Liang, C.; Ren, Y.; Zhen, Y.; He, Z.; Wang, H.; Tan, H.; Pan, X.; Wu, Z. Basic Res. Cardiol. 2009, 104, 42.   DOI
64 Dagia, N. M.; Agarwal, G.; Kamath, D. V.; Chetrapal-Kunwar, A.; Gupte, R. D.; Jadhav, M. G.; Dadarkar, S. S.; Trivedi, J.; Kulkarni- Almeida, A. A.; Kharas, F.; Fonseca, L. C.; Kumar, S.; Bhonde, M. R. Am J. Physiol. Cell Physiol. 2010, 298, C929.   DOI   ScienceOn
65 Park, J. S.; Gamboni-Robertson, F.; He, Q.; Svetkauskaite, D.; Kim, J. Y.; Strassheim, D.; Sohn, J. W.; Yamada, S.; Maruyama, I.; Banerjee, A.; Ishizaka, A.; Abraham, E. Am J. Physiol. Cell Physiol. 2006, 290, C917.