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http://dx.doi.org/10.5012/bkcs.2013.34.9.2707

N-Phenyl-3-Pyridin-2-yl Imino Derivatives as Vascular Smooth Muscle Relaxants: Potential Phosphodiesterase V Inhibitors  

Choudhari, Prafulla (Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy)
Bhatia, Manish (Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy)
Bhatia, Neela (Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.9, 2013 , pp. 2707-2710 More about this Journal
Abstract
The present communication deals with development of ten novel N-Phenyl-3-Pyridin-2-yl imino derivatives as vascular smooth muscle relaxants. The derivatives were prepared and optimized using pocket modelling and pharmacophore modelling. The 4 hydroxy substituted derivatives are showed potent activity comparable to the sildenafil.
Keywords
Goat aorta; Binding pocket; Phosphodiesterase V; Pharmacophore;
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