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http://dx.doi.org/10.5012/bkcs.2013.34.9.2604

Synthesis of 2,2'-Dipyrryl Ketones from Pyrrole-2-carboxylic Acids with Trifluoroacetic Anhydride  

Kim, Se Hee (Department of Chemistry and Institute of Basic Science, Chonnam National University)
Lim, Jin Woo (Department of Chemistry and Institute of Basic Science, Chonnam National University)
Yu, Jin (Department of Chemistry and Institute of Basic Science, Chonnam National University)
Kim, Jae Nyoung (Department of Chemistry and Institute of Basic Science, Chonnam National University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.9, 2013 , pp. 2604-2608 More about this Journal
Abstract
An efficient synthesis of 2,2'-dipyrryl ketones has been carried out from pyrrole-2-carboxylic acids using trifluoroacetic anhydride (TFAA). Simultaneous generation of both mixed anhydride and 2-unsubstituted pyrrole, via facile decarboxylation with in-situ generated TFA, made their cross reaction (intermolecular Friedel-Crafts acylation) possible and efficient.
Keywords
Dipyrryl ketones; Pyrrole-2-carboxylic acid; Trifluoroacetic anhydride; Mixed anhydride;
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