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http://dx.doi.org/10.5012/bkcs.2013.34.8.2330

Molecularly Imprinted Polymers for Solid-Phase Extraction of Sarcosine as Prostate Cancer Biomarker from Human Urine  

Hashemi-Moghaddam, Hamid (Department of Chemistry, Damghan Branch, Islamic Azad University)
Rahimian, Majid (Department of Chemistry, Damghan Branch, Islamic Azad University)
Niromand, Bahman (Department of Chemistry, Damghan Branch, Islamic Azad University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.8, 2013 , pp. 2330-2334 More about this Journal
Abstract
A highly selective molecularly imprinted polymer (MIP) for sarcosine, a cancer marker, was prepared and its use as solid-phase extraction (SPE) sorbent material was demonstrated. The MIP was prepared by a very simple procedure using methacrylic acid as functional monomer and a mixture acetonitrile/water (4/1, v/v) as porogen, overcoming in this way the problems usually related to the imprinting of biological polar compounds. The MIP was tested in batch experiments in order to evaluate its binding properties and then used as SPE sorbent for the selective clean-up and pre-concentration of sarcosine. The extraction protocol was successfully applied to the direct extraction of sarcosine from spiked human urine indicating that the MIP allowed sarcosine to be pre-concentrated while simultaneously interfering compounds were removed from the matrix.
Keywords
Sarcosine; Molecularly imprinted polymer; Solid-phase extraction; Cancer marker;
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1 Martínez-Lozano, P.; Rus, J. Journal of the American Society for Mass Spectrometry 2010, 21(7), 1129.   DOI   ScienceOn
2 Pätzold, R.; Brückner, H. Amino Acids 2006, 31(1), 63.   DOI   ScienceOn
3 Cavaliere, B.; Macchione, B.; Monteleone, M.; Naccarato, A.; Sindona, G.; Tagarelli, A. Analytical and Bioanalytical Chemistry 2011, 400(9), 2903.   DOI
4 Soleimani, M.; Ghaderi, S.; Afshar, M. G.; Soleimani, S., Microchemical Journal 2012, 100, 1.   DOI   ScienceOn
5 Zhang, Z.; Tan, W.; Hu, Y.; Li, G.; Zan, S. Analyst 2012, 137(4),968.   DOI   ScienceOn
6 Xia, X.; Lai, E. P.; Ormeci, B. Polymer Engineering & Science 2012, 52.8, 175.
7 Miura, D.; Fujimura, Y.; Yamato, M.; Hyodo, F.; Utsumi, H.; Tachibana, H.; Wariishi, H. Analytical Chemistry 2010, 82(23), 9789-9796.   DOI   ScienceOn
8 Cernei, N.; Zitka, O.; Ryvolova, M.; Adam, V.; Masarik, M.; Hubálek, J.; Kizek, R. Int. J. Electrochem. Sci. 2012, 7, 4286.
9 Wu, H.; Liu, T.; Ma, C.; Xue, R.; Deng, C.; Zeng, H.; Shen, X., Analytical and Bioanalytical Chemistry 2011, 401(2), 635-646.   DOI
10 Roobol, M. J.; Haese, A.; Bjartell, A. Acta Oncologica 2011, 50(S1), 85-89.   DOI   ScienceOn
11 Atieh, Z.; Allouche, A.; Lazariev, A.; Van Ormondt, D.; Graveron- Demilly, D.; Aubert-Frécon, M. Chemical Physics Letters 2010, 492(4), 297-301.   DOI   ScienceOn
12 Sadeghi, S.; Aboobakri, E. Microchimica Acta 2012, 178(1-2), 89.   DOI
13 Jentzmik, F.; Stephan, C.; Miller, K.; Schrader, M.; Erbersdobler, A.; Kristiansen, G.; Lein, M.; Jung, K. European Urology 2010, 58(1), 12.   DOI   ScienceOn
14 Jiang, Y.; Cheng, X.; Wang, C.; Ma, Y. Analytical Chemistry 2010, 82(21), 9022-9027.   DOI   ScienceOn
15 Sreekumar, A.; Poisson, L. M.; Rajendiran, T. M.; Khan, A. P.; Cao, Q.; Yu, J.; Laxman, B.; Mehra, R.; Lonigro, R. J.; Li, Y., Nature 2009, 457(7231), 910.   DOI   ScienceOn