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http://dx.doi.org/10.5012/bkcs.2013.34.5.1339

Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production  

Park, HoonGyu (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University)
Lee, Tae Hoon (Graduate School of Biotechnology and College of Life Sciences, Skin Biotechnology Center, Kyung Hee University)
Chang, Fei (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University)
Kwon, Hyun Ji (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University)
Kim, Jiyoung (Graduate School of Biotechnology and College of Life Sciences, Skin Biotechnology Center, Kyung Hee University)
Kim, Hakwon (Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.5, 2013 , pp. 1339-1344 More about this Journal
Abstract
We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of $100{\mu}M$.
Keywords
Glycosyl ergosterol; Glycosyl 5,6-dihydroergosterol; Glycosylation; Inhibitory activity; NO production;
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