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http://dx.doi.org/10.5012/bkcs.2013.34.3.887

An Efficient Synthesis of Substituted Furans by Cupric Halide-Mediated Intramolecular Halocyclization of 2-(1-Alkynyl)-2-alken-1-ones  

Fu, Wei-Jun (College of Chemistry and Chemical Engineering, Luoyang Normal University)
Xu, Feng-Juan (Chemistry Department, Zhengzhou University)
Guo, Wen-Bo (College of Chemistry and Chemical Engineering, Luoyang Normal University)
Zhu, Mei (College of Chemistry and Chemical Engineering, Luoyang Normal University)
Xu, Chen (College of Chemistry and Chemical Engineering, Luoyang Normal University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.3, 2013 , pp. 887-891 More about this Journal
Abstract
An efficient synthesis of 3-halofurans by the intramolecular cyclization of 2-(1-alkynyl)-2-alken-1-ones with cupric halide has been developed. A broad range of 3-chloro- and 3-bromofuran derivatives could be obtained in the present method in moderate to good yields. The 3-halofuran derivatives are potential synthetic intermediates for amplification of molecular complexity.
Keywords
Halofurans; Copper halide; Halogenation; Cyclization;
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