Browse > Article
http://dx.doi.org/10.5012/bkcs.2013.34.12.3782

Synthesis of Flavokawain B and its Anti-proliferative Activity Against Gefitinib-resistant Non-small Cell Lung Cancer (NSCLC)  

Seo, Young Ho (College of Pharmacy, Keimyung University)
Oh, Yong Jin (College of Pharmacy, Keimyung University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.12, 2013 , pp. 3782-3786 More about this Journal
Abstract
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and that accounts for 85% of lung cancer patients. Although several EGFR-targeted drugs have been developed in the treatment of NSCLC, the clinical efficacy of EGFR-targeted drugs in NSCLC is limited by the occurrence of drug resistance. In this regard, Hsp90 represents great promise as a therapeutic target of cancer due to its potential to simultaneously disable multiple signaling pathways. In this study, we discovered that a natural product, flavokawain B disrupted Hsp90 chaperoning function and impaired the growth of gefitinib-resistant non-small cell lung cancer (H1975). The result suggested that flavokawain B could serve as a potential lead compound to overcome the drug resistance in cancer chemotherapy.
Keywords
Flavokawain B; Hsp90; Gefitinib resistance; Natural product; Cancer;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Hanahan, D.; Weinberg, R. A. Cell 2000, 100, 57.   DOI   ScienceOn
2 Herbst, R. S.; Heymach, J. V.; Lippman, S. M. N Engl. J. Med. 2008, 359, 1367.   DOI   ScienceOn
3 Hanahan, D.; Weinberg, R. A. Cell 2011, 144, 646.   DOI   ScienceOn
4 Sordella, R.; Bell, D. W.; Haber, D. A.; Settleman, J. Science 2004, 305, 1163.   DOI   ScienceOn
5 Paez, J. G.; Janne, P. A.; Lee, J. C.; Tracy, S.; Greulich, H.; Gabriel, S.; Herman, P.; Kaye, F. J.; Lindeman, N.; Boggon, T. J.; Naoki, K.; Sasaki, H.; Fujii, Y.; Eck, M. J.; Sellers, W. R.; Johnson, B. E.; Meyerson, M. Science 2004, 304, 1497.   DOI   ScienceOn
6 Lai, B. T.; Chin, N. W.; Stanek, A. E.; Keh, W.; Lanks, K. W. Mol. Cell Biol. 1984, 4, 2802.
7 Mahalingam, D.; Swords, R.; Carew, J. S.; Nawrocki, S. T.; Bhalla, K.; Giles, F. J. Br. J. Cancer 2009, 100, 1523.   DOI   ScienceOn
8 Solit, D. B.; Chiosis, G. Drug. Discov. Today 2008, 13, 38.   DOI   ScienceOn
9 Chiosis, G.; Neckers, L. ACS Chem. Biol. 2006, 1, 279.   DOI
10 Whitesell, L.; Lindquist, S. L. Nat. Rev. Cancer 2005, 5, 761.   DOI   ScienceOn
11 Luo, W.; Sun, W.; Taldone, T.; Rodina, A.; Chiosis, G. Mol. Neurodegener 2010, 5, 24.   DOI   ScienceOn
12 Gallo, K. A. Chem. Biol. 2006, 13, 115.   DOI   ScienceOn
13 Peterson, L. B.; Blagg, B. S. Future Med. Chem. 2009, 1, 267.   DOI   ScienceOn
14 Li, J. W.; Vederas, J. C. Science 2009, 325, 161.   DOI   ScienceOn
15 Whitesell, L.; Mimnaugh, E. G.; De Costa, B.; Myers, C. E.; Neckers, L. M. Proc. Natl. Acad Sci. USA 1994, 91, 8324.   DOI   ScienceOn
16 Yu, Y.; Hamza, A.; Zhang, T.; Gu, M.; Zou, P.; Newman, B.; Li, Y.; Gunatilaka, A. A.; Zhan, C. G.; Sun, D. Biochem. Pharmacol. 2010, 79, 542.   DOI   ScienceOn
17 Hadden, M. K.; Galam, L.; Gestwicki, J. E.; Matts, R. L.; Blagg, B. S. J. Nat. Prod. 2007, 70, 2014.   DOI   ScienceOn
18 Marcu, M. G.; Chadli, A.; Bouhouche, I.; Catelli, M.; Neckers, L. M. J. Biol. Chem. 2000, 275, 37181.   DOI   ScienceOn
19 Steiner, G. G. Hawaii Med. J. 2000, 59, 420.
20 Agarwal, R.; Deep, G. Cancer Prev. Res. (Phila) 2008, 1, 409.   DOI   ScienceOn
21 Tang, Y.; Li, X.; Liu, Z.; Simoneau, A. R.; Xie, J.; Zi, X. Int. J. Cancer 2010, 127, 1758.   DOI   ScienceOn
22 Lin, E.; Lin, W. H.; Wang, S. Y.; Chen, C. S.; Liao, J. W.; Chang, H. W.; Chen, S. C.; Lin, K. Y.; Wang, L.; Yang, H. L.; Hseu, Y. C. J. Nutr. Biochem. 2012, 23, 368.   DOI   ScienceOn
23 Kobayashi, S.; Boggon, T. J.; Dayaram, T.; Janne, P. A.; Kocher, O.; Meyerson, M.; Johnson, B. E.; Eck, M. J.; Tenen, D. G.; Halmos, B. N Engl. J. Med. 2005, 352, 786.   DOI   ScienceOn
24 Hseu, Y. C.; Lee, M. S.; Wu, C. R.; Cho, H. J.; Lin, K. Y.; Lai, G. H.; Wang, S. Y.; Kuo, Y. H.; Kumar, K. J.; Yang, H. L. J. Agric. Food Chem. 2012, 60, 2385.   DOI   ScienceOn
25 Kachadourian, R.; Day, B. J.; Pugazhenti, S.; Franklin, C. C.; Genoux-Bastide, E.; Mahaffey, G.; Gauthier, C.; Di Pietro, A.; Boumendjel, A. J. Med. Chem. 2012, 55, 1382.   DOI   ScienceOn
26 Chiosis, G.; Vilenchik, M.; Kim, J.; Solit, D. Drug. Discov. Today 2004, 9, 881.   DOI   ScienceOn
27 Tang, Z.; Du, R.; Jiang, S.; Wu, C.; Barkauskas, D. S.; Richey, J.; Molter, J.; Lam, M.; Flask, C.; Gerson, S.; Dowlati, A.; Liu, L.; Lee, Z.; Halmos, B.; Wang, Y.; Kern, J. A.; Ma, P. C. Br. J. Cancer 2008, 99, 911.   DOI   ScienceOn