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http://dx.doi.org/10.5012/bkcs.2012.33.9.2907

3',4'-Dihydroxyl Groups in Luteolin are Important for Its Inhibitory Activities against ADAMTS-4  

Choi, Ji-Won (Drug Discovery Team, Bioinformatics & Molecular Design Research Center)
Jeong, Ki-Woong (Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University)
Kim, Jin-Kyoung (Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University)
Chang, Byung-Ha (Drug Discovery Team, Bioinformatics & Molecular Design Research Center)
Lee, Jee-Young (Drug Discovery Team, Bioinformatics & Molecular Design Research Center)
Kim, Yang-Mee (Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University)
Publication Information
Bulletin of the Korean Chemical Society / v.33, no.9, 2012 , pp. 2907-2909 More about this Journal
Abstract
A disintegrin and metalloprotease with thrombospondin domains (ADAMTS) are a member of peptidase and involved in processing of von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan. Among 19 subfamilies of human ADAMTS, ADAMTS-4 is a zinc-binding metalloprotease and is a famous therapeutic target for arthritis. It has been reported that a flavonoid luteolin shows inhibitory activity against ADMATS-4. In this study, we verified that luteolin is a potent inhibitor of ADAMTS-4 and probed the molecular basis of its action. On the basis of a docking study, we proposed a binding model between luteolin and ADAMTS-4 in which 3',4'-dihydroxyl groups in luteolin formed hydrogen bonding with ADMATS-4 and these interactions are important for its inhibitory activity against ADAMTS-4.
Keywords
ADAMTS-4; Metalloprotease; Flavonoid; Luteolin; Docking;
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