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http://dx.doi.org/10.5012/bkcs.2012.33.8.2623

Direct Palladium-Catalyzed C-4 Arylation of Tri-substituted Furans with Aryl Chlorides: An Efficient Access to Heteroaromatics  

Yang, Hai (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering)
Zheng, Zhishuo (Department of Physics, Guangdong University of Education)
Zeng, Jian (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering)
Liu, Huajie (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering)
Yi, Bing (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering)
Publication Information
Bulletin of the Korean Chemical Society / v.33, no.8, 2012 , pp. 2623-2626 More about this Journal
Abstract
A series of functionalized furans were synthesized by way of a palladium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of $BuAd_2P$ and t-BuOK in DMF at $120^{\circ}C$ after 15 h.
Keywords
Palladium catalyst; Coupling reaction; Furan; Arylation; Aryl chloride;
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