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http://dx.doi.org/10.5012/bkcs.2012.33.8.2603

Synthesis, Structure and Biological Properties of a Novel Copper (II) Supramolecular Compound Based on 1,2,4-Triazoles Derivatives  

Qiu, Guang-Mei (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Wang, Cui-Juan (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Zhang, Ya-Jun (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Huang, Shuai (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Liu, Xiao-Lei (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Zhang, Bing-Jun (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Zhou, Xian-Li (Department of Chemistry and Chemical Engineering, School of Life Science and Bioengineering, Southwest Jiaotong University)
Publication Information
Bulletin of the Korean Chemical Society / v.33, no.8, 2012 , pp. 2603-2608 More about this Journal
Abstract
A novel mononuclear supramolecule of copper(II) has been synthesized with Ippyt ligand (Ippyt=3-(4'-imidazole phenyl)-5-(pyrid-2''-yl)-1,2,4-triazole) (1). Compound 1, namely [$Cu(Ippyt)_2(H_2O)_2$], has been characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis and thermogravimetric analysis. Structure determination reveals that the elongated-octahedral geometry is formed in the vicinity of the copper (II) atom being coordinated by four nitrogen atoms from two Ippyt ligands occupying the equatorial position and two oxygen atoms from two coordinated water molecules in the axial position, which together form the $N_4O_2$ donor set. Hydrogen bonding interactions between nitrogen and oxygen atoms result in the set up of a supramolecular network architecture. Biological properties including antibacterial activity and superoxide dismutase (SOD) mimetic activity of compound 1 have been investigated by agar diffusion method and the modified Marklund method, respectively. The results indicate that compound 1 exhibits a stronger antibacterial efficiency than the parent ligand and it also has a certain radical-scavenging activity.
Keywords
Hydrogen bonding; Triazole; Copper (II); Antibacterial activity; SOD-like activity;
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Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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