[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2012.33.6.1834

Synthesis of Dimethyl Glutarate from Cyclobutanone and Dimethyl Carbonate over Solid Base Catalysts

Zhi, Chen (Center of Analysis, Guangdong Medical College)
Dudu, Wu (School of Pharmacy, Guangdong Medical College)

Publication Information

Bulletin of the Korean Chemical Society / v.33, no.6, 2012 , pp. 1834-1838 More about this Journal

Abstract

A facile route for the synthesis of dimethyl glutarate (DMG) from cyclobutanone and dimethyl carbonate (DMC) in the presence of solid base catalysts has been developed. It was found that the intermediate carbomethoxycyclobutanone (CMCB) was produced from cyclobutanone with DMC in the first step, and then CMCB was further converted to DMG by reacting with a methoxide group. The role of the basic catalysts can be mainly ascribed to the activation of cyclobutanone $via$ the abstraction of a proton in the ${\alpha}$ -position by base sites, and solid bases with moderate strength, such as MgO, favor the formation of DMG.

Keywords

Dimethyl glutarate; Cyclobutanone; Dimethyl carbonate; Solid base catalysts;

Citations & Related Records

Times Cited By Web Of Science : 0 (Related Records In Web of Science)

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