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http://dx.doi.org/10.5012/bkcs.2012.33.3.971

Facilitated Protein-DNA Binding: Theory and Monte Carlo Simulation  

Park, Ki-Hyun (School of Computational Sciences, Korea Institute for Advanced Study)
Kim, Tae-Jun (Department of Chemistry, Dong-A University)
Kim, Hyo-Joon (Department of Chemistry, Dong-A University)
Publication Information
Abstract
The facilitated diffusion effect on protein-DNA binding is studied. A rigorous theoretical approach is presented to deal with the coupling between one-dimensional and three-dimensional diffusive motions. For a simplified model, the present approach can provide numerically exact results, which are confirmed by the lattice-based Monte Carlo simulations.
Keywords
Diffusion-influenced reaction; Facilitated diffusion; Protein-DNA binding; Dimension reduction; Exact solution;
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