Browse > Article
http://dx.doi.org/10.5012/bkcs.2012.33.2.575

Discovery of Novel 1,4-Benzodioxane Containing Thiazolidinone Derivatives as Potential Antihepatotoxic Agent  

Khalilullah, Habibullah (Antihepatotoxic Research Laboratory, Faculty of Pharmacy)
Khan, Shamshir (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Qassim University)
Ahsan, Mohamed Jawed (Department of Pharmaceutical Chemistry, Alwar Pharmacy College)
Ahmed, Bahar (Antihepatotoxic Research Laboratory, Faculty of Pharmacy)
Publication Information
Bulletin of the Korean Chemical Society / v.33, no.2, 2012 , pp. 575-582 More about this Journal
Abstract
In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for antihepatotoxic activity against $CCl_4$-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.
Keywords
1,4-Benzodioxane; Thiazolidinone; Antihepatotoxic activity;
Citations & Related Records
 (Related Records In Web of Science)
연도 인용수 순위
  • Reference
1 Radha, K. D.; Yogesh, K. C. Dig. Dis. Sci. 2005, 50, 1807.   DOI   ScienceOn
2 Venkateswaran, S.; Pari, L.; Viswanathan, P.; Menon, V. P. J. Ethnopharmacol. 1997, 57, 161.   DOI   ScienceOn
3 Latha, U.; Rajesh, M. G.; Latha, M. S. Indian Drugs. 1999, 36, 470.
4 Mitra, S. K.; Seshadri, S. J.; Venkataranganna, M. V.; Gopumadhavan, S.; Udupa, V.; Sarma, D. N. K. Ind. J. Physiol. Pharmacol. 2000, 44, 82.
5 Dhuley, J. N.; Naik, S. R. J. Ethnopharmacol. 1997, 56, 159.   DOI   ScienceOn
6 Ahmed, B.; Khan, S. A.; Alam, T. Pharmazie. 2003, 58, 173.
7 Khan, S. A.; Ahmed, B.; Alam, T. Pak. J. Pharm. Sci. 2006, 19, 290.
8 Ahmed, B.; Habibullah.; Khan, S. J. Enz. Inh. Med. Chem. 2011, 26, 216.   DOI   ScienceOn
9 Chapleo, C. B.; Myers, P. L.; Butler, C. M.; Doxey, J. C.; Roach, A. G. J. Med. Chem. 1983, 26, 823.   DOI
10 Vazquez, M. T.; G. Rosell, M. D. Pujol. Eur. J. Med. Chem. 1997, 32, 529.   DOI   ScienceOn
11 Birch, A. M.; Bardley, P. A.; Gill, J. C.; Kerrigan, F.; Needham, P. L. J. Med. Chem. 1999, 42, 3342.   DOI   ScienceOn
12 Satzinger, G.; Herrmann, M. U. S. Patent 4,018,775, Apr. 19, 1977.
13 Khalilullah, H.; Khan, S.; Ahsan, M. J.; Ahmed, B. Bioorg. Med. Chem. Lett. 2011, 21, 7251.   DOI   ScienceOn
14 Reitman, S.; Frankel, S. Am. J. Clin. Pathol. 1957, 28, 56.   DOI
15 Kind, P. R. N.; King, E. J. J. Clin. Pathol. 1954, 7, 322.   DOI
16 Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. J. Biol. Chem. 1951, 193, 265.